Physiology of Trout Natriuretic Peptides

鳟鱼利钠肽的生理学

基本信息

  • 批准号:
    0235223
  • 负责人:
  • 金额:
    $ 40.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-02-01 至 2008-02-29
  • 项目状态:
    已结题

项目摘要

This study will examine the physiology of natriuretic peptides (NPs) in fish. NPs are a family of peptide hormones that decrease blood volume and lower blood pressure in virtually all vertebrates. NPs were first identified in mammals in 1981and although their genetic code was determined a few months later, their physiological function remains unknown to the present time. This proposal questions the applicability of mammalian models in NP research because mammals continually lose water through evaporation and renal excretion and thus are never naturally volume or pressure over-loaded. However, freshwater fish (trout) are chronically volume over-loaded and as the earliest vertebrates that contain all members of the NP family of proteins, they form the basis for the present study. Initially, specific assays will be developed for each trout NP (ANP, CNP, VNP). These assays will be used to determine how NP secretion is affected by independently manipulating water and salt balance via adapting trout to freshwater (volume overload, salt depletion), saltwater (volume depletion, salt overload), and freshwater plus high salt diet (volume and salt overload). Only euryhaline fish, such as trout, thrive in all these conditions and they are the only vertebrates in which these parameters can be controlled independently, non-invasively, and without stress. This information will then be used to examine the effects of physiological doses of NPs on trout fluid balance, in vivo and in vitro cardiovascular and renal function, and identify tissue-specific NP secretory processes. These studies will provide the first comprehensive picture of NP physiology from the vertebrates in which they initially evolved. This project is part of an international collaboration with laboratories in Canada and Japan and it will provide domestic and foreign training for graduate students and domestic training for undergraduates, teachers in secondary education, and high school students.
本研究旨在探讨鱼类利钠肽的生理特性。 NP是一种肽激素家族,几乎在所有脊椎动物中都能减少血容量和降低血压。 NPs于1981年首次在哺乳动物中被发现,尽管几个月后确定了它们的遗传密码,但它们的生理功能至今仍不清楚。 这一提议质疑哺乳动物模型在NP研究中的适用性,因为哺乳动物通过蒸发和肾排泄不断失去水分,因此从未自然地体积或压力过载。 然而,淡水鱼(鳟鱼)是长期体积超载,并作为最早的脊椎动物,包含所有成员的NP家族的蛋白质,他们形成的基础上,本研究。 最初,将为每种鳟鱼NP(ANP,CNP,VNP)开发特定的测定。这些试验将用于确定通过使鳟鱼适应淡水(体积超负荷,盐耗尽)、盐水(体积耗尽,盐过载)和淡水加高盐饮食(体积和盐过载)独立操纵水和盐平衡如何影响NP分泌。 只有广盐性鱼类,如鳟鱼,在所有这些条件下茁壮成长,它们是唯一的脊椎动物,这些参数可以独立控制,非侵入性,没有压力。 然后,这些信息将被用来检查生理剂量的NP对鳟鱼体液平衡,在体内和体外的心血管和肾功能的影响,并确定组织特异性NP分泌过程。 这些研究将提供第一个全面的图片NP生理学从脊椎动物,他们最初进化。 该项目是与加拿大和日本的实验室进行国际合作的一部分,将为研究生提供国内外培训,并为本科生、中学教师和高中生提供国内培训。

项目成果

期刊论文数量(0)
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Kenneth Olson其他文献

Walter H, Haaf R, Köhler S. Therapiemöglichkeiten der Depression nach Non-Response
Walter H、Haaf R、Köhler S. 抑郁症无反应治疗
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    O. Selawry;M. Krant;J. Scotto;E. Kazam;M. Schneiderman;Kenneth Olson;B. Shnider;J. Edmonson;J. Holland;S. Taylor
  • 通讯作者:
    S. Taylor
Methotrexate compared with placebo in lung cancer
甲氨蝶呤与安慰剂治疗肺癌的比较
  • DOI:
  • 发表时间:
    1977
  • 期刊:
  • 影响因子:
    6.2
  • 作者:
    O. Selawry;M. Krant;J. Scotto;E. Kazam;M. Schneiderman;Kenneth Olson;B. Shnider;J. Edmonson;J. Holland;S. Taylor
  • 通讯作者:
    S. Taylor
Loss of carbon-14 and mercury-203 labeled methylmercury from various solutions.
  • DOI:
    10.1021/ac50009a014
  • 发表时间:
    1977
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Kenneth Olson
  • 通讯作者:
    Kenneth Olson

Kenneth Olson的其他文献

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{{ truncateString('Kenneth Olson', 18)}}的其他基金

Reactive Sulfur Species: Challenging the Reactive Oxygen Species Paradigm
活性硫物种:挑战活性氧物种范式
  • 批准号:
    2012106
  • 财政年份:
    2020
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Continuing Grant
EAGER: Reactive Sulfide Species: Ubiquitous and Primordial Signaling Molecules
EAGER:反应性硫化物种类:普遍存在的原始信号分子
  • 批准号:
    1446310
  • 财政年份:
    2014
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Standard Grant
Hydrogen Sulfide: A Primal Vascular Oxygen Sensor
硫化氢:原始血管氧传感器
  • 批准号:
    1051627
  • 财政年份:
    2011
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Continuing Grant
Vascular Biology of Hydrogen Sulfide
硫化氢的血管生物学
  • 批准号:
    0641436
  • 财政年份:
    2007
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Continuing Grant
Extracellular Fluid Volume Homeostasis in Fish
鱼类细胞外液体积稳态
  • 批准号:
    9723306
  • 财政年份:
    1997
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Continuing Grant
Metabolism of Circulating Hormones by the Fish Gill
鱼鳃循环激素的代谢
  • 批准号:
    9105247
  • 财政年份:
    1991
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Continuing Grant
Scientific visit to write research results on air-breathing fishes. Travel Award in Indian Currency.
科学访问,撰写有关呼吸空气的鱼类的研究成果。
  • 批准号:
    9000944
  • 财政年份:
    1990
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Standard Grant
Metabolism of Circulating Hormones by the Fish Gill
鱼鳃循环激素的代谢
  • 批准号:
    9004245
  • 财政年份:
    1990
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Standard Grant
Metabolism of Circulating Hormones by the Fish Gill
鱼鳃循环激素的代谢
  • 批准号:
    8616028
  • 财政年份:
    1987
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Continuing Grant
Ecophysiological Studies of Some Metabolic and Respiratory Adaptations of Air-Breathing Fishes of India, SFC Award in US and Indian Currencies
印度呼吸空气鱼类的一些代谢和呼吸适应的生态生理学研究,美国和印度货币证监会奖
  • 批准号:
    8618881
  • 财政年份:
    1987
  • 资助金额:
    $ 40.79万
  • 项目类别:
    Standard Grant

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利用亲子三重基因组分析鉴定珊瑚鳟鱼“红色”突变的致病基因
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