Genealogical and Genetic Structure of Small Populations

小群体的谱系和遗传结构

• 批准号: 8619760
• 负责人: Elizabeth Thompson
• 金额: $ 12.6万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8619760&HistoricalAwards=false
• 关键词: Genealogical; Genetic; Structure; Small; Populations

In a small genetically isolated population, chance events of genealogy affect the genetic structure of the population, the number and variety of genes, and the pattern of similarity and difference between population subdivisions. Conversely, detailed patterns of genetic variation between individuals convey information about the recent genealogical history of the population, and thence about patterns of gene flow. The research proposed will develop methods to analyze effects of detailed genealogical structure upon gene survival, and for inference of genealogy from current genetic data. The latter question will be studied in a natural plant population. The methods developed will be applicable also to any other small natural animal or plant population, in which genetic data on individuals can be obtained but genealogical relationships cannot be precisely observed. The effects of genealogical structure on the number and variety of surviving genes in a small isolated population have implications for the genetic management of species isolates. Many species now exist only in small numbers and some only in captivity, and quantitative approaches to the maintenance of genetic variability can be of practical importance in assessing the future of a population. This research will also produce a package of computer programs to handle, store, access and update large complex genealogies within an efficient data base structure. These programs can provide a convenient data management structure for many persons involved in data of this type, whatever their computing expertise or objectives.

在一个少量的遗传孤立人群中，谱系的机会事件会影响人群的遗传结构，基因的数量和种类以及人口细分之间的相似性和差异的模式。 相反，个体之间遗传变异的详细模式传达了有关人群近期家谱史的信息，以及有关基因流动模式的信息。 提出的研究将开发方法来分析详细的谱系结构对基因存活的影响，以及从当前遗传数据中推断家谱。 后一种问题将在自然植物人群中进行研究。 开发的方法也适用于任何其他小型动物或植物种群，其中可以获得有关个体的遗传数据，但不能精确地观察到谱系关系。 谱系结构对少数孤立人群中存活基因的数量和种类的影响对物种分离株的遗传管理有影响。 现在，许多物种仅以少数数量存在，而仅在囚禁中存在，而维持遗传变异性的定量方法对于评估人群的未来可能至关重要。 这项研究还将生产一揽子计算机程序，以处理，存储，访问和更新有效的数据库结构中的大型复杂家谱。 这些程序可以为参与此类数据的许多人（无论其计算专业知识或目标）提供方便的数据管理结构。