International Symposium on Bombesin-Like Peptides

在过去的几年里，人们已经了解到， 像神经肽这样的分子对身体产生影响， 个脑袋 本次会议的目的是提供一个在- 蛙皮素样肽的各个方面的深入审查 研究和应用这些发现。 蛙皮素领域的进展已经加快了三个 体面的发展。 首先，是证明了 蛙皮素影响肠道功能的生物活性， 体内平衡的中枢调节 二是 哺乳动物蛙皮素样肽的表征，称为 胃泌素释放肽（GRP）和随后的克隆， 人GRP基因。 第三，发现蛙皮素和 哺乳动物相关肽作为一种重要的自分泌类型 人小细胞肺癌中的生长因子。 这些发现 已经导致了兴趣的扩散和多学科的 问题研究 特邀发言者将讨论与以下有关的问题 主题： 第一章 蛙皮素样肽的化学和分子生物学 包括蛙皮素cDNA的克隆和鉴定， 蛙皮素基因的翻译产物， （二） 蛙皮素样肽的组织分布和含量， 第三章 蛙皮素受体，定位，表征和 竞争性拮抗剂的开发进展， 四、 细胞、外周和中枢神经系统的作用 肽。 会议将首次提供一个论坛， 神经科学家，解剖学家，药理学家，胃肠病学家， 分子生物学家和肿瘤学家更新当前的研究 对蛙皮素样肽的活性，并描绘 进一步发展的领域，并确定未来的方向 特别是这些肽在正常和 恶性组织生长和调节肠道功能。 这本书 将由纽约科学院出版 会议的第一本全面的专著将是关于 话题吧

In the past few years, much has been learned about how small molecules like neuropeptides exert influence on the body and brain. The objectives of this conference are to provide an in- depth review of the various aspects of bombesin-like peptide research and applications of such findings. Progress in the bombesin field has been accelerated by three decent developments. First, was the demonstration of the potent biological activity of bombesin to influence gut function and the central regulation of homeostasis. Secondly, the characterization of mammalian bombesin-like peptides, called gastrin releasing peptide (GRP) and the subsequent cloning of the human GRP gene. Thirdly, was the discovery that bombesin and mammalian related peptides acts as an important autocrine type growth factor in human small cell lung cancer. These findings have lead to a proliferation of interest and multidisciplinary studies. Invited speakers will address issues related to the following topics: 1) Chemistry and molecular biology of bombesin-like peptides including cloning and characterization of bombesin cDNA and the translational products of bombesin genes, 2) Tissue distribution and content of bombesin-like peptides, 3) Bombesin receptors, localization, characterization and progress in the development of competitive anatagonists, 4) Cellular, peripheral and central nervous system actions of the peptide. The meeting will provide for the first time a forum for neuroscientists, anatomists, pharacologists, gastroenterologists, molecular biologists and oncologists to update current research activities on bombesin-like peptides and also to delineate the areas for further development and set up directions for coming years particularly the role of these peptides in normal and malignant tissue growth and regulation of gut function. The book to be published by the New York Academy of Sciences as a result of the meeting will be the first comprehensive monograph on the subject.