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Exploiting synthetic lethality in Renal Cell Carcinoma: Targeting the loss of the von Hippel-Lindau tumor suppressor gene through autophagy for the development of anticancer therapy

Exploiting synthetic lethality in Renal Cell Carcinoma: Targeting the loss of the von Hippel-Lindau tumor suppressor gene through autophagy for the development of anticancer therapy
利用肾细胞癌的合成致死性:通过自噬靶向 von Hippel-Lindau 肿瘤抑制基因的丢失,以开发抗癌疗法
批准号:
306309
负责人:
Turcotte Sandra
金额:
$36.13万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-03-01 至 2019-03-01

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中文摘要
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英文摘要
About 40,000 Americans and 5,100 Canadians will be diagnosed with kidney cancer this year resulting in about 13,000 and 1,800 deaths, respectively. At metastatic stages, there is no effective therapies to treat Renal Cell Carcinoma (RCC) since tumours are
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Characterization of PIKfyve as novel therapeutic target in clear cell Renal Cell Carcinoma
  • 批准号:
    472410
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Turcotte Sandra
  • 依托单位:
Targeting the loss of the von Hippel-Lindau tumor suppressor gene at a late-stage of autophagy for the development of anticancer therapy
  • 批准号:
    264837
  • 项目类别:
    Salary Programs
  • 资助金额:
    $7.65万
  • 财政年份:
    2012
  • 负责人:
    Turcotte Sandra
  • 依托单位:
海外基金