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Regulatory clamps and switches, and impact of disease-linked mutations in Cytidylyltransferase

Regulatory clamps and switches, and impact of disease-linked mutations in Cytidylyltransferase
监管钳位和开关，以及胞苷酰转移酶疾病相关突变的影响
批准号：
307268
负责人：
Cornell Rosemary B
金额：
$38.66万
依托单位：
Simon Fraser University (Burnaby, B.C.)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-03-01 至 2018-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=307268&lang=en
关键词：
Enzymology Fluorescence Spectroscopy Genetic Lipid Disorder Lipid-Protein Interactions Molecular Dynamics Simulation Protein Chemical Modification Protein Mutagenesis/Purification Protein Structure-Function-Regulation X-Ray Crystallography

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Cells that are growing rapidly need a ready supply of new cell membrane building blocks. The synthesis of the most abundant building block, phosphatidylcholine (PC) is controlled by an enzyme known as CCT. Many cellular enzymes, including CCT, have a cata
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