Regulation of Calcium Entry in Cerebral Arteries

钙通过电压依赖性钙通道进入动脉平滑肌细胞，调节收缩，从而调节血管内径和血流量。这项研究的总体目标是表征通过钙通道进入的钙在调节动脉平滑肌细胞收缩中所起的作用。钙内流的特征将通过检测单个钙通道结合到平面脂质双层和从大脑(基底)动脉分离的单个平滑肌细胞的膜斑块中的生理和药物调节来表征。本研究的结果将促进我们对血管平滑肌和钙通道功能的了解。

Calcium entry through voltage.dependent calcium channels into arterial smooth muscle cells regulates contraction and, therefore, blood vessel diameter, and blood flow. The overall goal of this research is to characterize the role that calcium entry through calcium channels plays in the regulation of contraction of smooth muscle cells in arteries. Calcium entry will be characterized by examining the physiological and pharmacological regulation of single calcium channels incorporated into planar lipid bilayers and in membrane patches from single smooth muscle cells isolated from cerebral (basilar) arteries. The results of this research will advance our understanding of vascular smooth muscle and calcium channel function.