Regulation of Calcium Entry in Cerebral Arteries

脑动脉钙进入的调节

• 批准号: 8702476
• 负责人: Mark Nelson
• 金额: $ 24万
• 依托单位: University of Vermont & State Agricultural College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8702476&HistoricalAwards=false
• 关键词: Regulation; Calcium; Entry; Cerebral; Arteries

Calcium entry through voltage.dependent calcium channels into arterial smooth muscle cells regulates contraction and, therefore, blood vessel diameter, and blood flow. The overall goal of this research is to characterize the role that calcium entry through calcium channels plays in the regulation of contraction of smooth muscle cells in arteries. Calcium entry will be characterized by examining the physiological and pharmacological regulation of single calcium channels incorporated into planar lipid bilayers and in membrane patches from single smooth muscle cells isolated from cerebral (basilar) arteries. The results of this research will advance our understanding of vascular smooth muscle and calcium channel function.

钙离子通过电压依赖性钙通道进入 进入动脉平滑肌细胞调节收缩， 从而影响血管直径和血流。 整体 这项研究的目的是描述钙在 通过钙通道进入， 动脉中平滑肌细胞的收缩。 钙进入 将通过检查生理和 单钙通道的药理学调节 结合到平面脂质双层和膜贴片中 从分离自大脑（基底动脉）的单个平滑肌细胞 动脉 这项研究的结果将促进我们的理解 血管平滑肌和钙通道功能的影响。