Conformational Analysis of Polysaccharides

多糖是自然界中最大的一类物质。它们存在于生命的每一种形式中，它们表现出复杂的结构，并与广泛的生物功能有关。它们的研究对于了解它们的结构、人口和生物学功能很重要。这些目标可以通过表征这些物质的构象、晶体和形态结构特征来实现。Sarko博士将在这个项目中使用衍射分析，主要是X-Rate和电子衍射。这些方法将得到以计算机为基础的模型分析的补充。这样做的目的既是为了提高结构分析的可靠性，也是为了使结构预测成为可能。将使用的建模技术将涉及分子和量子力学以及分子动力学的方法。

Polysaccharides are one of the largest classes of naturally occurring substances. They are found in every form of life where they exhibit complex structures and are associated with a wide range of biological functions. Their study is important in order to understand their structures, popoerties and biological functions. These goals can be achieved by the characterization of conformational, crystalline and morphological structural features of these substances. Dr. Sarko will use diffraction analysis, primarily X-rated and electron diffraction in this project. These methods will be complemented by computer- based model analysis. The purpose for this is both to increase the reliability of structural analysis and to make prediction of structure possible. The modeling techniques to be used will involve the methods of molecular and quantum mechanics and molecular dynamics.