Structure and Function of Regulatory Proteins

调节蛋白的结构和功能

• 批准号: 8704673
• 负责人: George Hess
• 金额: --
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8704673&HistoricalAwards=false
• 关键词: Structure; Function; Regulatory; Proteins

Dr. Hess is investigating the way in which the proteins that consititute the channels in cell membranes function as they recognize a signal in the environment and open or close to control the passage of ions. The movement of the ions then produces a signal that leads to a further event (muscle contraction, nerve conduction, hormone secretion, etc.). The investigator has developed techniques for the measurement of the very fast reactions that occur when an outside signal binds the membrane receptor, the channel opens, and ions flow. The specific system to be investigated with the current grant involves those that utilize acetyl choline as the external signal and in particular how phosphorylation of the membrane receptor affects its properties.

赫斯博士正在研究构成细胞膜通道的蛋白质在识别环境中的信号并打开或关闭以控制离子通过时的功能。然后离子的运动产生一个信号，导致进一步的事件（肌肉收缩、神经传导、激素分泌等）。研究者开发了一种技术，用于测量当外部信号与膜受体结合，通道打开，离子流动时发生的非常快速的反应。目前要研究的特定系统包括那些利用乙酰胆碱作为外部信号的系统，特别是膜受体的磷酸化如何影响其特性。