Structure-Function Studies of L-3-Hydorxyacyl Coenzyme A Dehydrogenase, Fumarase and Cytoplasmic Malate Dehydrogenase

L-3-羟基酰辅酶A脱氢酶、延胡索酸酶和细胞质苹果酸脱氢酶的结构-功能研究

• 批准号: 8706274
• 负责人: Leonard Banaszak
• 金额: $ 18.14万
• 依托单位: Washington University School of Medicine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-12-01 至 1989-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8706274&HistoricalAwards=false
• 关键词: Structure; Function; Studies; Hydorxyacyl; Coenzyme

For the understanding of the biochemical phenomena of enzyme activity data at the molecular level is one of the most vital needs. Dr. Banaszak is performing an X-ray crystallographic study of L-3 hydroxyacyl CoA Dehydrogenase (BHDH), cytoplasmic malate dehydrogenase (sMDH) and fumarase. Although these structural studies are at different stages, the long range objectives in each case are similar. Structural investigations of the type proposed are fundamental to understanding the mechanism of catalytic activity these enzymes which carry out essential steps in a number of fundamental biochemical pathways.

为了在分子水平上理解酶活性的生化现象，数据是最重要的需求之一。Banaszak博士正在对L-3羟酰辅酶A脱氢酶、细胞质苹果酸脱氢酶和富马酸酶进行X射线结晶学研究。尽管这些结构性研究处于不同阶段，但每个案例的长期目标都是相似的。所提出的这种类型的结构研究对于理解催化活性的机制是基本的，这些酶在许多基本的生化途径中执行必要的步骤。