Spatial Organization of Axonal Microtubules

轴突微管的空间组织

• 批准号: 8706741
• 负责人: Steven Heidemann
• 金额: $ 2万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-15 至 1989-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8706741&HistoricalAwards=false
• 关键词: Spatial; Organization; Axonal; Microtubules

Dr. Heidemann proposes to gather preliminary information about two areas related to microtubule organization and neuronal growth. He proposes investigations of a working hypothesis for control of microtubule assembly by the advancing growth cone. In this model, tension of the neurite is the result of tension within the actin-based cytoskeleton of the neuron. This tension is supported by internal microtubules and by the culture substratum, placing both under compression. Structurally, this arrangement is similar to the architectural principle of tensegrity developed some years ago by Buckminster Fuller. Of particular importance, thermodynamic considerations lead to the result that compression on MTs may regulate MT elongation and thus provide an economical method for integrating MT assembly with growth cone movement. Three of the specific goals are an investigation of the role of microtubules in the unusually clear regionalization of cultured neurons into cell body, neurite and growth cone compartments. These compartments differ in their cytoskeleton and in their cell surface/cell cortex activity. Results in this and other laboratories suggest microtubules may regulate the activity of the cell cortex.

Heidemann博士建议收集以下方面的初步信息： 这两个领域与微管组织和神经元 增长 他提出了一个工作假设的调查， 通过前进的生长锥控制微管组装。 在 在这个模型中，神经突的张力是张力的结果 在神经元的肌动蛋白细胞骨架中。 这种紧张 由内部微管和培养物支持 底层，将两者置于压力之下。 在结构上，这 布局类似于 张拉整体结构是几年前由巴克·富勒提出的。 的 特别重要的是，热力学考虑导致 结果，对MT的压缩可以调节MT的伸长， 从而提供了一种用于集成MT组件的经济方法 生长锥的运动。 三个具体目标是 研究微管在异常清晰的 将培养的神经元区域化为细胞体、神经突和 生长锥隔室。 这些隔间的不同之处在于 细胞骨架和它们的细胞表面/细胞皮层活性。 这个实验室和其他实验室的结果表明，微管可能 调节细胞皮层的活动。