Bioseparations in Multiple Support Magnetically Stabilized Fluidized Beds

多支撑磁稳定流化床中的生物分离

• 批准号: 8707636
• 负责人: Mark Burns
• 金额: $ 3.55万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1989-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8707636&HistoricalAwards=false
• 关键词: Bioseparations; Multiple; Support; Magnetically; Stabilized

The PI proposes to study the use of a magnetically stabilized fluidized bed (MSFB) to alleviate problems associated with the separation and purification of biochemicals obtained from fermentation broths and similar feed streams. To develop this continuous separation process, the PI plans to focus on two major objectives: - To gain an understanding of the behavior of a mixture of magnetic and nonmagnetic support materials in a liquid fluidized bed under an applied magnetic field. - To develop a new mode of using these liquid MSFBs as a counter-current contractor for protein purification. By using two materials in a MSFB, one can possibly eliminate the need to develop a new magnetic support material for each new biochemical separation to be performed. This proposal was considered by the Review Panel to be highly innovative and recommended funding for one year in accordance with the first year budget submitted with the proposal. The PI is considered to be well qualified to carry out the proposed research and I recommend funding in accordance with the Panel recommendation.

PI建议研究使用磁稳定 流化床（MSFB），以减轻与 生物化学品的分离和纯化， 发酵液和类似的进料流。 发展这种 连续分离过程中，PI计划重点放在两个主要的 目的： - 为了理解混合物的行为， 磁性和磁性支撑材料， 在外加磁场下的液体流化床。 - 为了开发一种新的模式，使用这些液体MSFB作为 用于蛋白质纯化的逆流承包商。 通过在MSFB中使用两种材料，可以消除 需要开发一种新的磁性支撑材料， 进行生化分离。 检讨委员会认为这项建议非常重要， 创新和建议的一年供资 第一年的预算与提案一起提交。 的PI 被认为是非常有资格进行拟议的 研究，我建议按照小组的资金 推荐