Bioseparations in Multiple Support Magnetically Stabilized Beds

多支撑磁稳定床中的生物分离

• 批准号: 8813830
• 负责人: Mark Burns
• 金额: $ 6.98万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1990-02-01
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8813830&HistoricalAwards=false
• 关键词: Bioseparations; Multiple; Support; Magnetically; Stabilized

Magnetic fields of sufficient strength are known to suppress mixing in fluidized beds of magnetically polarizable particles. This research concerns the fluid mechanical behavior of magnetically stablilized liquid fluidized beds using various mixtures of particles, some magnetically polarizable for bed stabilization, and some having specific adsorptive properties suitable for an efficient biochemical separation process. Stability of the bed will be investigated as a function of the particle sizes, densities and composition, liquid velocity, and magnetic field strength and orientation. The research will also examine protein separation in such beds. If successful stable operation of mixed particle fluidized beds can be achieved, it would permit greater flexibility in fluidized bed operations for biochemical separations and immediate adoption by the industry through the use of already existing non-magnetic particles having specialized adsorptive properties. The study should also yield interesting information on stabilization of liquid fluidized beds in magnetic fields.

已知足够强度的磁场可以抑制 在可磁极化颗粒的流化床中混合。 这项研究涉及的流体力学行为， 磁稳定液体流化床， 颗粒的混合物，一些可磁性极化的用于床 稳定化，并且一些具有特定的吸附性能 适用于有效的生化分离过程。 床层的稳定性将被研究为 颗粒尺寸、密度和组成、液体速度，以及 磁场强度和方向。 该研究还将 检查在这样的床中的蛋白质分离。 如果混合颗粒流化床成功稳定运行 可以实现，它将允许更大的灵活性，在流化床 用于生化分离和直接采用的床操作 通过使用现有的非磁性材料， 具有特殊吸附性能的颗粒。 研究 也应该产生关于稳定的有趣信息 磁场中的液体流化床。