Development of Pulse Field-Sweep EPR

这项建议要求提供资金，用于发展脉冲场扫描EPR(PFSEPR)，并扩大其作为探测电子、核和电子-电子自旋相互作用的简单但强大的工具的应用。这项技术将是技术复杂的Endor、Eldor和自旋回波方法的一种简单、经济的替代方法。主要研究人员建议提高PFSEPR的EPR灵敏度，提高其对大小超精细耦合的分辨率，并提高其解决动态相互作用的时间分辨率。他还将开发一个最小的PFSEPR修改，以便非专家更容易使用PFSEPR技术。斯科尔斯博士是为数不多的EPR/Endor专家之一，他拥有开发这种可能在化学和生化问题中广泛使用的工具所需的专业知识。

This proposal requests funds for the development of a pulse field-sweep EPR (PFSEPR) and to extend its application as a simple but powerful tool for probing electron nuclear and electron-electron spin interactions. This technique will be a simple, economical alternative to technically complex ENDOR, ELDOR, and spin echo methods. The prinicpal investigator proposes to improve the EPR sensitivity of PFSEPR, improve its resolution of both large and small hyperfine couplings, and improve its time resolution for resolving dynamic interactions. He will also develop a minimal PFSEPR modification so that the PFSEPR technique will become more accessible to the nonspecialist. Dr. Scholes, one of only a few EPR/ENDOR experts, has the expertise necessary to develop this tool that could be of wide use in chemical and biochemical problems.