Conference: Molecular Basis of the Immune Response, to be held on January 11, 12, 13, 1988, in New York City, NY.

会议：免疫反应的分子基础，将于 1988 年 1 月 11、12、13 日在纽约州纽约市举行。

• 批准号: 8713251
• 负责人: Constantin Bona
• 金额: $ 0.2万
• 依托单位: New York Academy of Sciences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-12-15 至 1988-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8713251&HistoricalAwards=false
• 关键词: Conference; Molecular; Basis; Immune; Response

During the past five years much progress has been made in elucidating the molecular basis of the immune response. The organization of genes encoding the specficity of the antigen receptor of B and T cells, as well as of genes encoding various lymphokines, was unravelled. Moreover the rearrangement of genes encoding lymphocytic receptor during the development of lymphocytes was demonstrated to be a unique and particular molecular event characteristic for lymphoid lineage. Important progress also occurred in understanding the organization of genes of the MHC locus, whose products function as genetic restriction elements that control the magnitude and affinity of antibody responses. The knowledge obtained from these fundamental studies has been extended to diseases and contributed to the understanding, function and the characteristics of V genes encoding antibodies and the role of MHC products in autoimmune diseases. The Conference on the Molecular Basis of the Immune Response, organized by Dr. Bona for the New York Academy of Sciences will review some of these advances as well as provide new insight on the function of lymphocytes in physiological and pathological conditions.

在过去的五年中，在阐明 免疫反应的分子基础 组织 编码B和T抗原受体特异性的基因 细胞，以及编码各种淋巴因子的基因， 解开了 此外，编码淋巴细胞的基因重排 在淋巴细胞发育过程中的受体被证明， 是一个独特的和特定的分子事件特征， 淋巴系 在理解方面也取得了重要进展 MHC基因座的基因组织，其产物功能 作为基因限制因素， 抗体反应的亲和力。从这些知识中获得的知识 基础研究已扩展到疾病，并有助于 对V基因的认识、功能和特性 编码抗体和MHC产物在自身免疫中的作用 疾病 免疫的分子基础会议 博纳博士为纽约科学院组织的回应 将回顾其中的一些进展，并提供新的见解， 淋巴细胞在生理和病理中的作用 条件