Study of Restriction Endonucleases, SFC Award in Pakistani Currency

目标和相关性：这项行动支持纽约长岛冷泉港实验室的Richard J.Roberts博士和巴基斯坦拉合尔旁遮普大学高级分子生物学中心的Sheikh Riazuddin博士之间的合作研究。这项研究将涉及生产多种具有新特性的新限制性内切酶，用于基因工程。人们将注意发现识别序列长于6个核苷酸的酶的方法，因为这种不经常切割DNA的酶对于绘制大基因组图(如人类基因组)具有重要价值。美国-巴基斯坦项目支持两国科学家的合作研究，两国的能力是互补的。这个项目很好地满足了这一标准。优点：这两位科学家是各自国家分子生物学领域最受尊敬的科学家之一。他们过去曾在科学研究方面进行合作，结果以联合论文的形式发表在国际期刊上。这一项目可能会产生可公布的成果，使该领域的其他工作人员受益。资金：该项目由两笔赠款提供资金；旁遮普大学，INT-8713479：FY87：SFC$22,925(巴基斯坦货币)冷泉港实验室，格兰特-8713519：87财年：20,925美元加证监会5,000美元88财年：22,181美元

Objective and Relevancy: This action supports collaborative research between Dr. Richard J. Roberts of Cold Spring Harbor Laboratory in Long Island, NY and Dr. Sheikh Riazuddin of the Center of Advanced Molecular Biology at the University of Punjab, Lahore, Pakistan. The research will involve production of a wide variety of new restriction enzymes with new specificities for use in genetic engineering. Attention will be paid to methods that allow the discovery of enzymes with recognition sequences longer than 6 nucleotides, since such enzymes which cleave DNA infrequently are of great value for mapping large genomes such as human genomes. The U.S.-Pakistan program supports cooperative research involving scientists from the two countries where capabilities complement each other. This project meets that criterion well. Merit: The two scientists are among the most highly regarded in the field of molecular biology in their respective countries. They have collaborated on scientific research in the past with results published as joint articles in international journals. This project is likely to produce publishable results which would benefit others working in the field. Funding: The project is being funded under two grants; University of Punjab, grant INT-8713479: FY87: SFC$22,925 (Pakistani Currency) Cold Spring Harbor Laboratory, grant INT-8713519: FY87: U.S.$20,925 plus SFC$5,000 FY88: U.S.$22,181