Molecular definition of cellular states in the vascular endothelium

血管内皮细胞状态的分子定义

• 批准号: DP230102958
• 负责人: Prof Kiarash Khosrotehrani
• 金额: $ 33.6万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-19 至 2026-01-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102958
• 关键词: Molecular; definition; cellular; states; vascular

The endothelium is the main cell type forming blood vessels and spans across multiple cell states from stem/progenitor to a variety of terminally differentiated cells. How each of these cell states are defined at the molecular level is not known preventing the optimal formation and integration of blood vessels in bioengineered tissues. Using innovative single cell gene expression and chromatin accessibility studies combined with innovative analysis, we propose to define and validate each cell state at the molecular level. This new knowledge would greatly enhance our ability to control the transition between cell states leading to a more widespread use of endothelial cells in bioengineering of tissues globally for many applications.

内皮是形成血管的主要细胞类型，并且跨越从干细胞/祖细胞到各种终末分化细胞的多种细胞状态。这些细胞状态中的每一种在分子水平上是如何定义的尚不清楚，这阻碍了生物工程组织中血管的最佳形成和整合。使用创新的单细胞基因表达和染色质可及性研究结合创新的分析，我们建议在分子水平上定义和验证每个细胞状态。 这一新知识将大大提高我们控制细胞状态之间转换的能力，从而使内皮细胞在全球组织生物工程的许多应用中得到更广泛的应用。