Potency and activity of Meso-Endothelial bipotent progenitors in vivo

体内内皮双能祖细胞的效力和活性

• 批准号: DP190103187
• 负责人: Prof Kiarash Khosrotehrani
• 金额: $ 24.57万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-14 至 2022-02-13
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103187
• 关键词: Potency; activity; Meso; Endothelial; bipotent

This project aims to characterise a new stem cell population that can maintain both blood vessels and contribute to a variety of tissues whether fibrous, bone, fat or cartilage. Blood vessels comprise an inner endothelial layer and surrounding mesenchyme, are integral to many organs and constitute a unique system connecting different parts of the body. Despite their importance little is known about how they are maintained and how they contribute to the response to injury. Previous work has described several populations of stem cell capable of self renewal and repletion of the endothelium or the mesenchyme. This project will examine the potency of these different progenitors to give rise to each of these fates in homeostasis but also during sounding and bone formation. This will help define a unique population of stem cells capable of both vascular and mesenchymal repair.

该项目旨在培养一种新的干细胞群，可以维持血管并有助于各种组织，无论是纤维，骨骼，脂肪或软骨。血管包括内内皮层和周围的间充质，是许多器官的组成部分，并构成连接身体不同部位的独特系统。尽管它们很重要，但人们对它们是如何维持的以及它们如何促进对损伤的反应知之甚少。以前的工作已经描述了几个群体的干细胞能够自我更新和补充的内皮或间充质。该项目将研究这些不同的祖细胞在体内平衡中以及在发声和骨形成过程中引起这些命运中的每一种的潜力。这将有助于确定一个独特的干细胞群体能够血管和间充质修复。