Structure, Binding, and Dynamics of Arabinogalactan- Proteins

阿拉伯半乳聚糖蛋白质的结构、结合和动力学

• 批准号: 8716179
• 负责人: Eugene Nothnagel
• 金额: $ 17.88万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8716179&HistoricalAwards=false
• 关键词: Structure; Binding; Dynamics; Arabinogalactan; Proteins

A class of macromolecules known as arabinogalactan-proteins (AGPs), that are present both at the outside surface of the plasma membrane and in the cell wall space of plant cells, will be investigated. Because AGPs have the ability to bind carbohydrates and are localized on the surface of the plasma membrane, they may play an important role at the membrane- cell wall interface in terms of cellular responses. The main objectives of the investigation are to compare the structure of AGPs on the cell wall with that of AGPs in plasma membrane, to study AGP interaction with some antigens, to characterize an enzyme that destroys the carbohydrate binding properties of plasma membrane AGPs, and to characterize the interaction between the AGPs and the plasma membrane with those in the cell wall. The project will increase our knowledge about the structural components of plasma membrane in plant cells and interaction of those components with the cell wall. Knowledge gained from this could eventually lead to a better understanding of cell adhesion, water retention, disease resistance and cell-cell recognition in plant cells.

一类称为阿拉伯半乳聚糖蛋白（AGPs）的大分子， 存在于质膜的外表面和 植物细胞的细胞壁空间将被研究。 因为AGP 具有结合碳水化合物的能力并位于表面 它们可能在细胞膜上起着重要的作用- 细胞壁界面的细胞反应。 主要目标 研究的目的是比较细胞上AGP的结构， 细胞壁与AGP在质膜上的相互作用，以研究AGP与 一些抗原，以表征破坏碳水化合物的酶， 结合特性的质膜AGPs，并表征 AGPs和质膜之间的相互作用与 细胞壁 该项目将增加我们对结构的了解， 植物细胞质膜组分及其相互作用 与细胞壁。 从中获得的知识可以 最终能更好地理解细胞粘附，水 保持、抗病性和细胞-细胞识别。