Acquisition of an Automated Circular Dichroism Spectrometer and Accessories

这是一个请求资金获得自动通知 二色性（CD）光谱仪，将用于五个主要的 立体化学分析、生物分子研究的用户 结构、合成蛋白质分析和电子 谱 个别项目是，首先， DNA结构扰动的研究 调节蛋白结合。 第二，研究了 合成蛋白质和蛋白质折叠的成核作用。 三是 肽和蛋白质构象研究。 第四， 研究致癌物与DNA的相互作用。 最后，研究了二次加工中的微观畴 髓鞘碱性蛋白结构和甲基化。

This is a request for funds to obtain an automated circular dichroism (CD) spectrometer which will be utilized by five major users in studies of stereochemical analysis, biomolecular structure, synthetic protein analysis and electronic spectroscopy. The individual projects are, first, an investigation of structural perturbations induced in DNAs by regulatory protein binding. Second, a study of structures of synthetic proteins and nucleation of protein folding. Third, a study of peptide and protein conformation. Fourth, an investigation of the interaction of carcinogens with DNA. Finally, a study of microscopic domains in the secondary structure and methylation of myelin basic protein.