Alkylation Reactions Involving Electron Transfer

涉及电子转移的烷基化反应

• 批准号: 8717871
• 负责人: Glen Russell
• 金额: $ 47.56万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-01-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8717871&HistoricalAwards=false
• 关键词: Alkylation; Reactions; Involving; Electron; Transfer

This grant in Organic and Macromolecular Chemistry provides support for work by Dr. Glen A. Russell, Iowa State University, focused on the one-electron reduction or oxidation of neutral radicals in chain and non-chain processes. The work extends to the application of free radical chain processes involving alkylmercury halides with the primary objective of developing selective additive alkylation processes for electron-poor and electron-rich substituted alkenes. It is believed that such alkenes, which yield adduct radicals that can be classified as acceptor or donor species, can be induced to participate in chain reactions by electron transfer between the adduct radicals and added donor acceptor molecules or ions. The added donor or acceptor molecule or ion will be chosen so that electron transfer yields a new radical or radical ion capable of rapidly reacting with the alkylmercury halide to regenerate an alkyl radical. The study also involves physical organic studies on the reactivity of alkyl radicals, particularly towards unsaturated systems, and includes new studies concerning the regiochemistry of radical attack, the stereoselectivity of radical addition and the stereospecificity of radical substitution occurring by an addition-elimination sequence. This data will be applied in a diagnostic fashion to establish or eliminate the presence of radical processes in reactions of other organometallic tert-butylating agents.

有机和高分子化学的这项资助提供了 支持Glen A博士的工作。罗素，爱荷华州州立大学， 重点是中性的单电子还原或氧化 链和非链过程中的自由基。 工作延伸到 自由基链式反应的应用， 卤化烷基汞，主要目的是开发 用于贫电子和 富电子取代烯烃。据信此类 烯烃，其产生加合物自由基，可被分类为 受体或供体物种，可以被诱导参与 加合物间电子转移链式反应 自由基和添加的供体受体分子或离子。 增加 选择供体或受体分子或离子 电子转移产生新的自由基或自由基离子， 与卤化烷基汞快速反应， 烷基。 这项研究还涉及对 烷基自由基的反应性，特别是对不饱和 系统，并包括有关区域化学的新研究 自由基攻击，自由基加成的立体选择性 以及通过以下方式发生的自由基取代的立体特异性 一个加消序列 这些数据将应用于 一种诊断方式来建立或消除存在的 其他有机金属反应中的自由基过程 叔丁基化剂。