Defining novel immune checkpoints controlled by stromal cells

定义由基质细胞控制的新型免疫检查点

• 批准号: DP230102854
• 负责人: Prof Mariapia Degli-Esposti
• 金额: $ 34.45万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-10-27 至 2026-10-26
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102854
• 关键词: Defining; novel; immune; checkpoints; controlled

This project seeks to use innovative approaches to elucidate the mechanisms that define the earliest steps required to generate immune responses. The proposal builds on discoveries, including novel preliminary data, from a team with world-leading expertise in immunology, virology and stromal cell biology. The expected findings will provide fundamental insights into novel cellular and molecular interactions between stromal tissue components and immune cells that initiate and regulate immune responses. Expected benefits include fundamental advances in knowledge, as well as insights that will ultimately benefit biotechnology and therapeutic applications, and in this way support research priorities linked to advanced manufacturing and health.

该项目寻求使用创新方法来阐明确定产生免疫反应所需的最早步骤的机制。该提案建立在一个在免疫学、病毒学和基质细胞生物学方面拥有世界领先专业知识的团队的发现基础上，包括新的初步数据。预期的发现将为基质组织成分和免疫细胞之间的新的细胞和分子相互作用提供基本的见解，这些相互作用启动和调节免疫反应。预期的好处包括知识的根本进步，以及最终将有利于生物技术和治疗应用的见解，从而支持与先进制造和健康有关的研究优先事项。