Transport Characteristics of Renal Tubules of the Avian Kidney

禽肾肾小管的运输特性

• 批准号: 8718483
• 负责人: Gary Laverty
• 金额: $ 19.37万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-15 至 1991-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8718483&HistoricalAwards=false
• 关键词: Transport; Characteristics; Renal; Tubules; Avian

This proposal describes experiments that will attempt to elucidate details of the transport functions (i.e. reabsorption from urine to blood) in the avian kidney. Such details for this vertebrate group have been lacking until recently. The bird kidney appears morphologically like a hybrid of kidneys found in reptiles and in mammals. This makes the bird kidney an interesting model for study of the adaptative features of the two kidney types. In addition, the avian kidney appears to possess some transport features that may be unique among vertebrates, and may therefore provide new insight into cellular diversity of function. This work will specifically use micropuncture and electrophysiological techniques to study fluid and electrolyte transport in superficial, "reptilian-type" nephrons. In addition, hormonal regulation of transport activity will be studied.

该提案描述了试图阐明禽肾转运功能（即从尿液到血液的重吸收）细节的实验。 直到最近，有关这一脊椎动物群体的详细信息一直缺乏。 鸟类肾脏在形态上类似于爬行动物和哺乳动物肾脏的混合体。 这使得鸟肾成为研究两种肾类型适应性特征的有趣模型。 此外，鸟类肾脏似乎具有一些脊椎动物中独特的运输特征，因此可能为细胞功能多样性提供新的见解。 这项工作将专门使用微穿刺和电生理学技术来研究浅表“爬行动物型”肾单位中的液体和电解质转运。 此外，还将研究运输活动的激素调节。