Equipment for Structural Biology

结构生物学设备

• 批准号: 8720134
• 负责人: Sung-Hou Kim
• 金额: $ 134.52万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8720134&HistoricalAwards=false
• 关键词: Equipment; Structural; Biology

This award provides funds for the purchase of a high-field NMR spectrometer and computer equipment, and of an X-ray generator, area detector and associated smaller items. The equipment will be shared by an group of outstanding structural biologists at the University of California at Berkeley. Studies to be performed by the group include experimental studies of the structure and function of enzymes, of other proteins and of self-splicing and other RNAs. More theoretical work aimed at prediction of protein structure will also be undertaken. The development and application of 2-dimensional NMR spectroscopy and X-ray crystallography to the study of the structure and function of biological macromolecules like RNA and protein is currently one of the most exiting areas of biological research. Although NMR instruments have been available for many years, it is only within the last few years that high field instruments with the requisite resolution and sensitivity for such studies have been developed. Similarly, the development of X-ray area detectors and of high speed computers has made the acquisition and interpretation of X-ray crystallographic data a relatively routine procedure. Thus, equipment of the type to be purchased with these funds now plays a vital role in the progress of our understanding of macromolecular structure.

该奖项为购买高场NMR提供资金 光谱仪和计算机设备，以及X射线发生器， 探测器和相关的较小物品。 设备将由以下人员共享： 一群杰出的结构生物学家， 加州伯克利分校。 该小组将进行的研究包括 酶的结构和功能的实验研究， 蛋白质和自我剪接和其他RNA。 更多理论工作 还将开展旨在预测蛋白质结构的研究。 二维核磁共振波谱技术的发展与应用 和X射线晶体学的结构和功能的研究 RNA和蛋白质等生物大分子是目前最重要的生物大分子之一。 生物学研究的最新领域。 虽然核磁共振仪器 已经有很多年了，只是在过去的几年里， 多年来，高场仪器与必要的决议， 这种研究的敏感性已经开发出来。 类似地， X射线面探测器和高速计算机的发展， 进行了X射线晶体学数据的采集和解释， 一个相对常规的程序。 因此，设备的类型是 用这些资金购买，现在在进步中发挥着至关重要的作用， 我们对大分子结构的理解。