Equipment: Helium Recovery Equipment: Securing Rhode Island and Southern New England NMR structural biology infrastructure

设备: 氦回收设备: 确保罗德岛州和新英格兰南部 NMR 结构生物学基础设施的安全

基本信息

  • 批准号:
    2233775
  • 负责人:
  • 金额:
    $ 32.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-15 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

An award is made to Brown University to support the acquisition of helium recovery equipment to recycle the helium used by the three nuclear magnetic resonance (NMR) spectrometers in the Structural Biology Core Facility at Brown University. Used by researchers at Brown, in Rhode Island, and across southeastern New England, the NMR spectrometers at Brown University employ extremely high magnetic fields to see the structure, motions, and interactions of proteins and biomolecules involved in essential biological processes with atomic resolution. The Brown structural biology facility is also an important component of efforts by researchers in the region to make broad and sustained educational impacts, encouraging underserved Rhode Island school students into the STEM pipeline – including classroom teaching, training of students from groups under-represented in science, and collecting data and serving as training platform as part of a sustained interactions with local underserved public schools. These NMR spectrometers use superconducting magnets cooled by liquid helium to a few degrees above absolute zero to maintain superconductivity needed for these high magnetic fields. As a result, helium constantly boils off NMR systems and escapes to the atmosphere. Hence, a constant supply of helium is needed for the maintenance and operation of the instruments. Helium is an expensive and non-renewable resource, so it is fiscally and environmentally responsible to recycle helium. The global supply of helium is currently in an extreme shortage due to manufacturing and supply chain conditions. The liquid helium recycling systems acquired with support from this award will capture and re-liquefy the helium released from NMR spectrometers and offer high efficiency recovery of all helium used for NMR operation. The project enables acquisition of the helium liquification and collection equipment necessary for recycling approximately 2200 liters of liquid helium per year for three magnet systems. The 850 MHz NMR (highest magnetic field in Rhode Island and second highest in New England) requires refills every few weeks – hence the facility is severely endangered by short-term supply outages. This project stabilizes helium supply, providing the important added benefit of lengthening time between 850 MHz system fills, enabling more usage time per year. The work enabled by the spectrometers served by these helium recovery efforts provides atomic-level insight into 1) the function of essential glutamine-rich domains of nucleic-acid interacting proteins across all eukaryotes and the mechanisms that regulate their interactions, 2) allosteric signaling in Cas9 to yield first-of-its-kind insight into DNA editing to further improve laboratory science and precision medicine, 3) peptide-protein interaction kinetics to modulate and study cellular networks, among other projects. Helium recycling ensures the ability to continue these efforts, the first steps in long-term objectives to map mechanistic links between biological sequence, structure and function.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
向布朗大学提供了一项奖励,以支持购买氦回收设备,以回收布朗大学结构生物学核心设施中三台核磁共振(NMR)光谱仪所使用的氦。布朗大学的核磁共振波谱仪由布朗大学的研究人员使用,位于罗得岛,横跨新英格兰东南部。布朗大学的核磁共振波谱仪采用极高的磁场,以原子分辨率观察蛋白质和生物分子的结构、运动和相互作用,这些蛋白质和生物分子参与了基本的生物过程。布朗结构生物学设施也是该地区研究人员努力产生广泛和持续教育影响的重要组成部分,鼓励服务不足的罗得岛学校学生进入STEM管道-包括课堂教学,培训来自科学代表性不足的群体的学生,收集数据并作为培训平台,作为与当地服务不足的公立学校持续互动的一部分。这些NMR光谱仪使用超导磁体,由液氦冷却到绝对零度以上几度,以保持这些高磁场所需的超导性。因此,氦不断地从NMR系统中蒸发并逃逸到大气中。因此,仪器的维护和操作需要持续的氦气供应。氦气是一种昂贵且不可再生的资源,因此回收氦气对环境和经济都是负责任的。由于制造和供应链条件,全球氦气供应目前处于极度短缺状态。在该奖项的支持下获得的液氦回收系统将捕获和重新分配从NMR光谱仪释放的氦,并提供用于NMR操作的所有氦的高效回收。该项目可以采购氦液化和收集设备,每年为三个磁体系统回收约2200升液氦。850 MHz核磁共振(罗得岛磁场最高,新英格兰磁场第二高)需要每隔几周重新填充一次,因此该设施受到短期停电的严重威胁。该项目稳定了氦气供应,提供了延长850 MHz系统填充之间时间的重要额外好处,每年可以使用更多的时间。这些氦回收工作所服务的光谱仪所实现的工作提供了原子水平的洞察:1)所有真核生物中核酸相互作用蛋白质的必需谷氨酰胺丰富结构域的功能以及调节其相互作用的机制,2)Cas9中的变构信号传导,以产生对DNA编辑的首次洞察,以进一步改善实验室科学和精密医学,3)肽-蛋白质相互作用动力学,以调节和研究细胞网络等项目。氦回收确保了继续这些努力的能力,这是长期目标的第一步,以绘制生物序列,结构和功能之间的机械联系。该奖项反映了NSF的法定使命,并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Nicolas Fawzi其他文献

Visualizing Structural Details of Disordered Domain Phase Separation Associated with ALS and Cancers
  • DOI:
    10.1016/j.bpj.2016.11.046
  • 发表时间:
    2017-02-03
  • 期刊:
  • 影响因子:
  • 作者:
    Nicolas Fawzi
  • 通讯作者:
    Nicolas Fawzi

Nicolas Fawzi的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Nicolas Fawzi', 18)}}的其他基金

CAREER: Structural aspects of glutamine-rich domain liquid-liquid phase separation in transcription and RNA processing
职业:转录和 RNA 加工中富含谷氨酰胺域液-液相分离的结构方面
  • 批准号:
    1845734
  • 财政年份:
    2019
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Continuing Grant

相似海外基金

MRI: Acquisition of Helium Recovery Equipment For Time-Resolved ARPES at NSF-NeXUS
MRI:在 NSF-NeXUS 采购用于时间分辨 ARPES 的氦回收设备
  • 批准号:
    2320634
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
MRI: Track 3 Acquisition of Helium Recovery Equipment at West Virginia University
MRI:第 3 轨道采购西弗吉尼亚大学氦回收设备
  • 批准号:
    2320495
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
Equipment: Helium Recovery Equipment: Critical Helium Recycling System for CSUN to Preserve NMR Access for Research and Teaching
设备:氦气回收设备:CSUN 的关键氦气回收系统,以保留 NMR 用于研究和教学的通道
  • 批准号:
    2304705
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
Equipment: Helium Recovery Equipment for a Regional NMR and EPR Laboratory at Wayne State University
设备:韦恩州立大学区域 NMR 和 EPR 实验室的氦气回收设备
  • 批准号:
    2303622
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
Equipment: Helium Recovery Equipment: Acquisition of a Helium Recovery and Liquefaction System for the IU NMR Facility
设备:氦回收设备:为 IU NMR 设施购置氦回收和液化系统
  • 批准号:
    2304987
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
MRI: Track 3 Acquisition of Helium Recovery Equipment - Closed-cycle Cryotraps for Polar Ice Core Trace Gas Analysis
MRI:轨道 3 采购氦回收设备 - 用于极地冰芯痕量气体分析的闭路低温冷阱
  • 批准号:
    2319563
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
Acquisition of Helium Recovery Equipment: Orbitrap Fourier Transform Isotope Ratio Mass Spectrometer for Environmental and Climate Research.
购置氦回收设备:Orbitrap 傅里叶变换同位素比质谱仪,用于环境和气候研究。
  • 批准号:
    2318987
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
MRI: Track 3 Acquisition of Helium Recovery Equipment to Enhance Research and Training in Earth Sciences and Chemistry
MRI:第 3 轨道采购氦回收设备以加强地球科学和化学的研究和培训
  • 批准号:
    2319922
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
MRI: Acquisition of Helium Recovery Equipment: An integrated system for helium capture and recovery for the Oregon State University NMR facility
MRI:采购氦回收设备:俄勒冈州立大学 NMR 设施的氦捕获和回收集成系统
  • 批准号:
    2320189
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
MRI: Track 3 Acquisition of Helium Recovery Equipment to Establish a Sustainable NMR Facility at the University of Toledo
MRI:第 3 轨道采购氦回收设备,在托莱多大学建立可持续的 NMR 设施
  • 批准号:
    2320218
  • 财政年份:
    2023
  • 资助金额:
    $ 32.23万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了