Mechanistic Singlet Oxygen Chemistry

有机和高分子化学的这项资助提供了 支持爱德华·克伦南博士的研究，大学 怀俄明州。工作重点是单线态氧的反应。这 氧的形式是受激的或高能的。一些 与衰老有关的生物学过程被认为包括 单线态氧及其反应基本认识 因此，化学与重要的生物学密切相关。 问题 单重态氧与H_2O反应的机理研究 将研究富电子二烯和硫化物。的 探针单线态氧反应底物的合成 电子转移和非对映体辅助效应， 进行。 溶剂、温度和添加剂的影响 在这些反应中形成的产物分布 将检查具有单线态氧的衬底。 低 温度NMR将用于检测中间体， 在1200 nm处的单线态氧发射将被监测， 这些底物的存在以获得重要的 动态信息单线态氧的分子内捕获 中间体将用亚砜捕集基团进行处理。 分子内捕获具有对称性的优点， 可以确定关于中间体的信息。效果 取代基对亚砜捕集能力的影响 将认真审查各小组。

This grant in Organic and Macromolecular Chemistry provides support for the research of Dr. Edward Clennan, University of Wyoming. The work focuses on reactions of singlet oxygen. This form of oxygen is an excited or energetic one. A number of biological processes related to aging are thought to involve singlet oxygen and a fundamental understanding of its reaction chemistry is, thus, closely linked to important biological problems. Mechanistic studies of the reactions of singlet oxygen with electron rich dienes and with sulfides will be studied. The synthesis of substrates to probe singlet oxygen reactions for electron transfer and anchimeric assistance effects will be undertaken. The effect of solvent, temperature, and additives on product distributions formed in the reactions of these substrates with singlet oxygen will be examined. Low temperature NMR will be utilized to detect intermediates and the emission of singlet oxygen at 1200nm will be monitored in the presence of these substrates in order to obtain important kinetic information. Intramolecular trapping of singlet oxygen intermediates will be pursued with sulfoxide trapping groups. Intramolecular trapping has the advantage that symmetry information on the intermediate can be ascertained. The effect of substitutents on the trapping ability of the sulfoxide groups will be carefully examined.