U.S.-Federal Republic of Germany Joint Seminar on Dynamics of Protein Development and Function, Heidelberg (June 26 - July 1, 1988)

美国-德意志联邦共和国蛋白质发育和功能动力学联合研讨会，海德堡（1988年6月26日至7月1日）

• 批准号: 8722194
• 负责人: Hans Neurath
• 金额: $ 1.2万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-15 至 1988-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8722194&HistoricalAwards=false
• 关键词: U.S.; Federal; Republic; Germany; Joint

This award supports the participation of approximately ten U.S. scientists in a workshop with West German colleagues to discuss the current status and future developments in research on the evolution of protein structure and function. This largely bilateral meeting was co-organized by Professors Hans Neurath of the University of Washington and Robert Zwilling of the University of Heidelberg. Heidelberg has become one of the leading centers of molecular biology in the Federal Republic of Germany. Discussions by an outstanding group of U.S. and FRG protein chemists and molecular biologists will focus on the structure, function and evolution of specific proteins and protein systems that have been selected due to their particular biological functions, their unique structures and/or their evolutionary interest. The meeting should lead to a more active integration of molecular biology, protein chemistry and the study of protein evolution, and advance efforts to understand the factors that determine the folding pattern of protein structures, the expression of their function and the evolution of complex protein molecules. Current interest in protein evolution in general, and in phylogeny and ontogeny in particular, derives from the realization that proteins are composed of structural and functional domains which are the products of gene splicing and shuffling. While in the past, analysis of structure/function relationships has been directed toward the protein molecule as a whole, this approach has changed with the realization that all but the smallest protein molecules are assemblies of substructures or domains which have been recruited in the course of evolution from seemingly unrelated sources in the gene pool. The relation of domains to the organization of the genomic DNA is one of the most intriguing problems facing the molecular biologist interested in protein evolution. Many of the topics of the meeting are also relevant to the processes and potential uses of biotechnology.

该奖项支持大约10名美国人参与。 科学家们在一个研讨会上与西德的同事讨论 进化研究的现状与发展 蛋白质的结构和功能。 这次主要是双边会谈 是共同组织的教授汉斯Neurath的大学 华盛顿和海德堡大学的罗伯特·双情愿。 海德堡已成为领先的分子生物学中心之一， 生物学在联邦共和国的德国。 讨论会 美国和联邦德国蛋白质化学家和分子生物学家的杰出团队 生物学家将专注于结构，功能和进化， 特定的蛋白质和蛋白质系统已经被选择， 它们独特的生物学功能，它们独特的结构 和/或他们的进化兴趣。 会议应导致一个 分子生物学、蛋白质化学和 研究蛋白质进化，并进一步努力了解 决定蛋白质折叠模式的因素 结构，其功能的表达和进化 复杂的蛋白质分子。 目前的兴趣在蛋白质的进化一般，并在遗传学 尤其是个体发育学， 蛋白质由结构和功能域组成， 基因剪接和重组的产物。 在过去， 结构/功能关系的分析已被导向 对于蛋白质分子整体而言， 除了最小的蛋白质分子， 已经被招募的子结构或域的组装， 从基因中看似无关的来源进化的过程 池 结构域与基因组结构的关系 DNA是分子生物学面临的最有趣的问题之一， 对蛋白质进化感兴趣的生物学家 的许多主题 这些会议还与下列方面的进程和潜在用途有关： 生物技术.