Crystal Purity Habit and Size Distribution from Batch Crystallization

结晶是生产高价值精细和特种化学品、生物化学品和药品的重要工艺。然而，这一过程仍然是一门艺术，而不是科学。拟议的研究旨在为这一过程建立科学基础。四种模式氨基酸的结晶将在间歇结晶器和连续结晶器中进行研究。我们将对晶体成核和生长的机制有一个了解。这一结果将对结晶领域产生直接影响，也将扩大其在生物分离和纯化方面的应用。

Crystallization is an important process for producing high-value fine and specialty chemicals, biochemicals and pharmaceuticals. The process remains, however, as an art rather than science. The proposed research is aimed at establishing a scientific basis for the process. The crystallization of four model amino acids will be studied in both batch and continuous crystallizers. An understanding will be obtained for the mechanism of crystal nucleation and growth. The results will have direct impact on the field of crystallization and also expanding its application to bioseparation and purification.