U.S.-Switzerland Cooperative Research on the Application of a Unified Theory of Gas-Liquid Chromatography

该奖项支持乔治敦大学的Daniel E. Martire博士与瑞士洛桑联邦理工学院的Ervin Kovats教授在分离过程中的合作研究。他们的合作利用了Martire博士在理论分析方面的专业知识和Kovats教授在新型化学合成方面的专业知识，以及他们在气液色谱（GLC）测量热力学溶液性质方面的共同优势。他们研究的主要目的是在完善的分子理论基础上，开发更可靠、定量、相关和预测的GLC保留方法。他们已经完成了对表征良好的系统的实验研究，精心选择以显示广泛的分子链长度和相互作用效应。Martire博士现在计划将一种新的色谱统一理论应用于热力学结果的理论分析。他们合作的另一个目标是指导GLC的极性和极化标准液相的合成，以瑞士开发的Apolane化合物为基础。色谱法是最重要的和广泛使用的仪器方法，用于化学混合物的物理分离，最终鉴定和定量。然而，许多分析色谱仍然以经验的方式进行，这既耗时又常常不可靠，特别是当遇到新的分离化合物时。本研究的结果将促进更明智和有效的方法来评估GLC分离，通过指导选择或设计最有效的流动相和固定相为给定的分离。

This award supports Dr. Daniel E. Martire of Georgetown University for cooperative research in separation processes with Professor Ervin Kovats of the Ecole Polytechnique Federal of Lausanne, Switzerland. Their collaboration draws on the respective expertise of Dr. Martire in theoretical analysis and Prof. Kovats in novel chemical synthesis, and on their common strength in the measurement of thermodynamic solution properties by gas-liquid chromatography (GLC). The primary objective of their research is to develop more reliable and quantitative, correlative and predictive methods for GLC retention, based on sound molecular theory. They have completed experimental studies on well-characterized systems, carefully selected to display a wide range of molecular chain length and interactional effects. Dr. Martire now plans to apply a novel unified theory of chromatography to the theoretical analysis of the thermodynamic results. A further objective of their collaboration is to guide the synthesis of polar and polarizable standard liquid phases for GLC, based on the Apolane compounds developed in Switzerland. Chromatography is the most important and widely used instrumental method for the physical separation of mixtures of chemical compounds, and ultimately their identification and quantification. However, much analytical chromatography is still practiced in an empirical manner, which is both time consuming and often unreliable, especially when novel separation compounds are encountered. The results of this research will promote a more informed and efficient approach to assessing GLC separations, by guiding the selection or design of the most effective mobile and stationary phases for a given separation.