U.S.-Switzerland Cooperative Research on the Application of a Unified Theory of Gas-Liquid Chromatography

这个奖项支持博士丹尼尔E。乔治城大学 与教授合作研究分离过程 洛桑联邦理工学院的埃尔文·科瓦茨， Switzerland. 他们的合作利用了各自的专业知识， 马蒂尔博士在理论分析和科瓦茨教授在小说 化学合成，以及它们在测量中的共同优势 用气液色谱法测定溶液的热力学性质 （GLC）。 他们研究的主要目标是开发更多的 可靠的、定量的、相关的和预测的方法， GLC保留，基于健全的分子理论。 他们已经完成 实验研究的良好特征的系统，仔细 选择以显示宽范围的分子链长度， 干扰效应 马蒂尔博士现在计划将一本小说 色谱统一理论的理论分析 热力学结果 他们合作的另一个目标是 指导极性和可极化标准液的合成 GLC的阶段，基于开发的Apolane化合物 Switzerland. 色谱法是最重要和最广泛使用的仪器 化学品混合物的物理分离方法 化合物，并最终对其进行鉴定和定量。 然而，许多分析色谱法仍然在工业中实践。 经验的方式，这是既费时，往往不可靠， 特别是当遇到新的分离化合物时。 的 这项研究的结果将促进一个更知情和更有效的 评估GLC分离的方法， 最有效的移动的和固定相的设计， 在分离的情况下。

This award supports Dr. Daniel E. Martire of Georgetown University for cooperative research in separation processes with Professor Ervin Kovats of the Ecole Polytechnique Federal of Lausanne, Switzerland. Their collaboration draws on the respective expertise of Dr. Martire in theoretical analysis and Prof. Kovats in novel chemical synthesis, and on their common strength in the measurement of thermodynamic solution properties by gas-liquid chromatography (GLC). The primary objective of their research is to develop more reliable and quantitative, correlative and predictive methods for GLC retention, based on sound molecular theory. They have completed experimental studies on well-characterized systems, carefully selected to display a wide range of molecular chain length and interactional effects. Dr. Martire now plans to apply a novel unified theory of chromatography to the theoretical analysis of the thermodynamic results. A further objective of their collaboration is to guide the synthesis of polar and polarizable standard liquid phases for GLC, based on the Apolane compounds developed in Switzerland. Chromatography is the most important and widely used instrumental method for the physical separation of mixtures of chemical compounds, and ultimately their identification and quantification. However, much analytical chromatography is still practiced in an empirical manner, which is both time consuming and often unreliable, especially when novel separation compounds are encountered. The results of this research will promote a more informed and efficient approach to assessing GLC separations, by guiding the selection or design of the most effective mobile and stationary phases for a given separation.