U.S.-Switzerland Cooperative Research on the Application of a Unified Theory of Gas-Liquid Chromatography

该奖项支持乔治城大学的Daniel E.Martin博士与瑞士洛桑联邦理工学院的Ervin Kovats教授在分离过程中的合作研究。他们的合作利用了Martin博士在理论分析方面和Kovats教授在新型化学合成方面的各自专业知识，以及他们在用气-液色谱(GLC)测量热力学溶液性质方面的共同优势。他们研究的主要目标是基于健全的分子理论，开发更可靠、更定量、更相关和更具预测性的GLC保留方法。他们已经完成了对特征良好的体系的实验研究，精心挑选，以展示广泛的分子链长和相互作用的影响。马特尔博士现在计划将一种新的统一的色谱学理论应用于热力学结果的理论分析。他们合作的另一个目标是指导基于瑞士开发的Apolane化合物的GLC极性和可极化标准液相的合成。层析是对化合物混合物进行物理分离，并最终对其进行鉴定和定量的最重要和最广泛使用的仪器方法。然而，许多分析层析仍然是以经验的方式进行的，这既耗时又往往不可靠，特别是当遇到新的分离化合物时。这项研究的结果将通过指导对给定分离最有效的流动相和固定相的选择或设计，促进更知情和更有效的方法来评估GLC分离。

This award supports Dr. Daniel E. Martire of Georgetown University for cooperative research in separation processes with Professor Ervin Kovats of the Ecole Polytechnique Federal of Lausanne, Switzerland. Their collaboration draws on the respective expertise of Dr. Martire in theoretical analysis and Prof. Kovats in novel chemical synthesis, and on their common strength in the measurement of thermodynamic solution properties by gas-liquid chromatography (GLC). The primary objective of their research is to develop more reliable and quantitative, correlative and predictive methods for GLC retention, based on sound molecular theory. They have completed experimental studies on well-characterized systems, carefully selected to display a wide range of molecular chain length and interactional effects. Dr. Martire now plans to apply a novel unified theory of chromatography to the theoretical analysis of the thermodynamic results. A further objective of their collaboration is to guide the synthesis of polar and polarizable standard liquid phases for GLC, based on the Apolane compounds developed in Switzerland. Chromatography is the most important and widely used instrumental method for the physical separation of mixtures of chemical compounds, and ultimately their identification and quantification. However, much analytical chromatography is still practiced in an empirical manner, which is both time consuming and often unreliable, especially when novel separation compounds are encountered. The results of this research will promote a more informed and efficient approach to assessing GLC separations, by guiding the selection or design of the most effective mobile and stationary phases for a given separation.