Histone H3.3-dependent transcriptional control and B cell differentiation

该项目旨在研究细胞组装转录机器以打开基因并保留转录记忆的基本方式。该项目预计将产生新的知识，在染色质生物学和免疫学领域，使用跨学科的方法。该项目的预期成果包括通过机构和国际合作提高能力，以确定对刺激作出反应的免疫记忆的快速转录和功能特征是否是由于组蛋白H3变体及其相关的核体。这应该提供显着的好处，如理解表观遗传机制，在许多物种的转录启动和维护的基础。

This project aims to investigate the fundamental way cells assemble transcriptional machinery to turn on genes and retain transcriptional memory. This project expects to generate new knowledge in the areas of both chromatin biology and immunology, using interdisciplinary approaches. Expected outcomes of this project include an enhanced capacity, through institutional and international collaborations, to determine whether the rapid transcription and function characteristic of immune memory in response to stimuli is due to histone H3 variant and its associated nuclear bodies. This should provide significant benefits, such as understanding epigenetic mechanisms that underlie transcription initiation and maintenance across many species.