Epigenetic regulation of centromere and telomere chromatin

着丝粒和端粒染色质的表观遗传调控

• 批准号: FT140100128
• 负责人: Prof Lee Wong
• 金额: $ 47.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100128
• 关键词: Epigenetic; regulation; centromere; telomere; chromatin

Epigenetics is a system that turns genes on and off without sequence alterations in the DNA. This process works by attaching chemical tags, known as epigenetic marks, to DNA. Centromeres and telomeres are chromosomal DNA domains essential for faithful chromosome segregation and genome stability. Their function and structural integrity are tightly regulated by specific epigenetic marks. This project aims to assess the functions of key epigenetic factors including chromatin remodelers, histone variants and non-coding RNA in controlling centromere and telomere activity. The data should describe novel pathways that maintain the identity, transcription silencing, DNA replication fidelity and structural stability at these domains.

表观遗传学是一种在不改变DNA序列的情况下打开和关闭基因的系统。这个过程的工作原理是将化学标签（称为表观遗传标记）附着在DNA上。着丝粒和端粒是染色体DNA结构域，对染色体的可靠分离和基因组的稳定性至关重要。它们的功能和结构完整性受到特定表观遗传标记的严格调控。本项目旨在评估关键的表观遗传因子包括染色质重塑因子、组蛋白变体和非编码RNA在控制着丝粒和端粒活性中的功能。这些数据应该描述新的途径，保持身份，转录沉默，DNA复制保真度和结构稳定性在这些领域。