Reading the sequence of a single molecule of DNA

读取单个 DNA 分子的序列

• 批准号: DP230102655
• 负责人: A/Prof Lawrence Lee
• 金额: $ 34.67万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102655
• 关键词: Reading; sequence; single; molecule; DNA

This project seeks to develop technology capable of accurately reading the sequence of a single DNA molecule for the first time. This is possible by combining state-of-the-art methods in DNA self-assembly, single-molecule fluorescence microscopy and bioelectronics, to overcome fundamental limits in current technologies. The outcome of accurate DNA sequencing at single molecule resolution, promises ground-breaking biological insight from a more fine-grained view of the genetic world, game-changing technologies such as point-of-care genomics and in turn a substantial impact on the rapidly growing multi-billion-dollar DNA sequencing market.

该项目旨在开发能够首次准确阅读单个DNA分子序列的技术。通过结合DNA自组装、单分子荧光显微镜和生物电子学中的最先进方法，这是可能的，以克服当前技术的根本限制。 以单分子分辨率进行精确DNA测序的结果，有望从更精细的遗传世界视角获得突破性的生物学见解，改变游戏规则的技术，如即时基因组学，进而对快速增长的数十亿美元DNA测序市场产生重大影响。