Differential requirements of the transcription factor IRF5 in the generation and maintenance of T-cell responses during visceral leishmaniasis

内脏利什曼病期间 T 细胞反应的产生和维持中转录因子 IRF5 的差异要求

• 批准号: 248648
• 负责人: Stager Simona
• 金额: $ 7.29万
• 依托单位: INRS-Institut Armand-Frappier (Laval)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2012-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=248648&lang=en
• 关键词: Adoptive Transfer; Cell-Specific Knock-Outs; Inflammation; Mice; Parasitic Infection; Signalling; T-Cell Responses

Upon encounter with a pathogen, the organism reacts by generating an inflammatory response. This response is aimed at killing the pathogen, but can also damage the tissue. Hence, the organism must maintain a balance between inflammation and tissue protect

当遇到病原体时，生物体会产生炎症反应。这种反应旨在杀死病原体，但也可能损害组织。因此，机体必须在炎症和组织保护之间保持平衡。