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Differential requirements of the transcription factor IRF5 in the generation and maintenance of T-cell responses during visceral leishmaniasis

Differential requirements of the transcription factor IRF5 in the generation and maintenance of T-cell responses during visceral leishmaniasis
内脏利什曼病期间 T 细胞反应的产生和维持中转录因子 IRF5 的差异要求
批准号：
252068
负责人：
Stager Simona
金额：
$52.63万
依托单位：
INRS-Institut Armand-Frappier (Laval)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-03-01 至 2017-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252068&lang=en
关键词：
Adoptive Transfer Cell-Specific Knock-Outs Inflammation Mice Parasitic Infection Signalling T-Cell Responses

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英文摘要
Upon encounter with a pathogen, the organism reacts by generating an inflammatory response. This response is aimed at killing the pathogen, but can also damage the tissue. Hence, the organism must maintain a balance between inflammation and tissue protect
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Mechanisms of visceral leishmaniasis pathogenesis and implications for host-directed therapy development
  • 批准号：
    478479
  • 项目类别：
    Operating Grants
  • 资助金额：
    $86.94万
  • 财政年份：
    2023
  • 负责人：
    Stager Simona
  • 依托单位：
    INRS - (Qubec, QC)
Interferon regulatory factor 5: a new player in T cell biology
Differential requirements of the transcription factor IRF5 in the generation and maintenance of T-cell responses during visceral leishmaniasis