Research Initiation: Species Transport Across Polymerized Vesicle Membranes

研究启动：跨聚合囊泡膜的物种运输

• 批准号: 8810283
• 负责人: Vinayak Kabadi
• 金额: $ 8万
• 依托单位: North Carolina Agricultural & Technical State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-15 至 1991-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8810283&HistoricalAwards=false
• 关键词: Research; Initiation; Species; Transport; Across

The objective of this project is to examine the transport rate in polymers as a means of assessing the feasibility of using synthetic polymerized vesicles as separation vehicles to concentrate selected species from dilute solutions. The unique advantage enjoyed by the polymerized vesicles is that their membranes are very thin, typically five nanometers. As such, the species transport rate can be greatly enhanced. Two specific issues will be addressed in this work: the effect of polymerization on membrane permeabilities; and the incorporation of chemical carriers with preserved functional activities in polymerized vesicles membranes. The labeled tracer technique will be used to study the membrane permeability. Marker leakage tests will be conducted to evaluate the stability of polymerized vesicles after the incorporation of chemical carriers. The activities of chemical carriers in polymeric membranes will be compared with those in monomeric membranes. Vesicles are of considerable research interest in the area of drug delivery, separation technology, solar energy conversion, catalysis, and chemical sensing. The transport results from this project will establish the long term framework for the study of polymerized vesicles as separation vehicles in an uphill active transport mode.

本项目的目标是研究聚合物中的传输速率，以此作为评估使用合成聚合泡囊作为分离载体从稀溶液中浓缩特定物种的可行性。聚合囊泡的独特优势是它们的膜非常薄，通常是5纳米。因此，可以极大地提高物种的传输速度。这项工作将解决两个具体问题：聚合对膜通透性的影响；以及在聚合囊泡膜中加入具有保留功能活性的化学载体。利用标记示踪技术研究膜的通透性。将进行标记泄漏试验，以评估在加入化学载体后聚合囊泡的稳定性。化学载体在聚合物膜中的活性将与在单体膜中的活性进行比较。囊泡在药物传递、分离技术、太阳能转换、催化和化学传感等领域具有重要的研究价值。该项目的运输结果将为研究聚合囊泡作为上坡主动运输模式下的分离载体建立长期框架。