Cooperative Research on Photoaffinic Labelling of Compounds with Pyrene

芘化合物光亲和标记合作研究

• 批准号: 8814467
• 负责人: J. Kerry Thomas
• 金额: $ 1.18万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-15 至 1991-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8814467&HistoricalAwards=false
• 关键词: Cooperative; Research; Photoaffinic; Labelling; Compounds

This award supports cooperative research in photochemistry between J. Kerry Thomas of Notre Dame University and Andres Olea of the University of Chile in Santiago. The work will involve the photolabelling of organic (biological) compounds with pyrene. Such photoreactions have been studied at both universities with this specific work having its start at Notre Dame. The approach will include the location of the pyrene, whether in the choline region, or close to the glycerol or to the alkane chain region and also the production of derivatives of pyrene for probing other systems such as micelles, vesicles, simple alkanes and polyelectrolytes. Techniques already in use are fast pulse kinetics at Notre Dame and steady state kinetics in Chile. These will complement each other to establish the mechanisms by which the probe molecules: pyrene, azopyrene and azidopyrene form the addition products with the host medium. Chile's strength is in product analysis and that of Notre Dame is in fast pulse analysis of earlier events. This cooperation will lead to the development of photochemical mechanisms of great use to the photochemical and colloid community.

该奖项支持圣母大学的J.Kerry Thomas和圣地亚哥智利大学的Andres Olea在光化学方面的合作研究。这项工作将涉及用芘对有机(生物)化合物进行光标记。这两所大学都对这种光反应进行了研究，这项具体的工作始于巴黎圣母院。该方法将包括芘的位置，无论是在胆碱区，还是靠近甘油或烷烃链区，以及产生用于探测胶束、小泡、简单烷烃和聚电解质等其他体系的芘的衍生物。已经在使用的技术是巴黎圣母院的快速脉冲动力学和智利的稳态动力学。这些将相辅相成，以建立探针分子：芘、偶氮并和叠氮并与宿主介质形成加成产物的机制。智利的优势在于产品分析，巴黎圣母院的优势在于对早期事件的快速脉冲分析。这种合作将导致开发对光化学和胶体社区非常有用的光化学机制。