Effect of Peroxide Pre-oxidation on Microbial Degradation of Toxic Wastes

这是美国国家科学基金会女性研究机会下的职业进步奖。本研究的目的是研究诱导氧化在有毒化学物质生物降解处理前的作用。由于它们的流行程度、组成差异和预期反应，选择了三种突出的模型毒素进行研究。通过添加过氧化物酶和过氧化氢试剂，研究了过氧化氢的氧化作用。针对每种模型化合物，选择来自有毒废物场所的微生物进行微生物降解过程。测定了每种模型化合物在有和没有过氧化氢形式的情况下的生物降解率。由于预氧化而加速的生物降解是由这些速率的差异决定的。

This is a Career Advancement award under NSF's Research Opportunities for Women. The objective of the research is to study the role of induced oxidation prior to biodegradation treatment of toxic chemicals. Three prominent model toxins have been chosen for study due to their prevalence, differences in composition, and expected response. Hydrogen peroxide oxidation is studied by adding peroxidase enzyme and hydrogen peroxide chemical. Microbes from toxic waste sites specific for each model compound is selected for the microbial degradation process. Biodegradation rates for each model compound with and without the forms of hydrogen peroxide is determined. The acceleration of biodegradation due to pre-oxidation is determined by the difference in these rates.