Metal Vinylidenes and Carbenes in Synthetic Organic Chemistry

有机合成项目支持西北大学安东尼·巴雷特教授的工作。巴雷特教授正在研究与碳相连的金属，有机金属化合物，如何为制备结构复杂的分子提供独特的方法。该项目将研究这些有机金属化合物如何反应的细节，以及它们使用的局限性。将特别关注制造化学环状化合物的方法。含环化合物是自然界常见的，有机化学家的重要任务之一就是在实验室中找到新的方法来构建自然界中可以找到的化合物。阳离子的应用ironıII！偏乙烯试剂对构建杂环和碳环分子的多样性进行了研究。这些反应将集中在杂环和碳环的新环化方法上。本研究将探讨有机金属试剂反应模式的基本问题。随着新开发技术的范围逐渐为人所知，这些方法将被应用于设计合成有机化学家感兴趣的分子骨架的有效路线。

The Organic Synthesis Program is supporting the work of Prof. Anthony Barrett of Northwestern University. Prof. Barrett is studying how metals connected to carbon, organometallic compounds, can provide unique methods for preparing structurally complex molecules. The project will study the details of how these organometallic compounds react, and the limitations of their use. Special attention will focus on methods for making chemical ring compounds. Ring-containing compounds are common to Nature, and one of the important missions of organic chemists is to find new ways to build, in the laboratory, the kinds of compounds that can be found in Nature. The application of cationic ironıII! vinylidene reagents to the construction of a diversity of heterocyclic and carbocyclic molecules will be investigated. The reactions will be focused on novel cyclization approaches to heterocyclic and carbocyclic rings. The research will explore the fundamental questions of the mode of reactivity of the organometallic reagents. As the scope of the newly-developing technology becomes known, the methods will be applied to designing efficient routes to molecular skeletons of interest to synthetic organic chemists.