Gold Vinylidenes and Gold Aryne Complexes: Novel Reactive Intermediates for Versatile Synthetic Applications

金亚乙烯基和金芳炔配合物：用于多种合成应用的新型反应中间体

• 批准号: 1301343
• 负责人: Liming Zhang
• 金额: $ 42万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1301343&HistoricalAwards=false
• 关键词: Gold; Vinylidenes; Aryne; Complexes; Novel

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Liming Zhang of Department of Chemistry at the University of California, Santa Barbara, aims to study the reactivities of two novel and reactive gold intermediates, gold vinylidene and gold aryne complex, and develop versatile reactions based on them that would be operationally simple, high yielding, and robust and offer unique/unprecedented access to important new skeletons. These procedures will be used in the synthesis of highly complex natural and unnatural products such as polycyclic hydrocarbons and heterocycles. Successful implementation of these strategies will provide for the rapid assembly of a variety of polycyclic systems, including some less commonly found in the chemical literature. Ready access to privileged ligand frameworks may also be achieved. Successful outcomes should have an impact on any area of chemical activity where the syntheses of novel molecules are needed, such as in the pharmaceutical, agricultural and chemical industries. Moreover, the project promises to provide excellent training vehicles of students at all levels, including those from historically underrepresented groups.

本项目由加州大学圣巴巴拉分校化学系化学合成项目资助，旨在研究两种新型的活性金中间体--亚乙烯基金和芳炔基金的反应性，并以此为基础开发操作简单、产率高、和强大的，并提供独特的/前所未有的访问重要的新骨架。这些程序将用于合成高度复杂的天然和非天然产物，如多环烃和杂环。这些策略的成功实施将提供各种多环系统的快速组装，包括一些在化学文献中不太常见的多环系统。也可以实现对特权配体框架的容易获得。成功的结果应该对任何需要合成新分子的化学活动领域产生影响，例如制药，农业和化学工业。此外，该项目还承诺为各级学生提供出色的培训工具，包括来自历来代表性不足群体的学生。