Gold Vinylidenes and Gold Aryne Complexes: Novel Reactive Intermediates for Versatile Synthetic Applications

在这个由化学系化学合成计划资助的项目中，加州大学圣巴巴拉分校化学系的张黎明教授旨在研究两种新型的、活性的金中间体--亚乙烯基金和芳香络合物的反应性，并基于它们开发操作简单、产量高、稳定性好的多功能反应，并提供独特/前所未有的重要新骨架的访问途径。这些程序将用于合成高度复杂的天然和非天然产物，如多环烃和杂环。这些策略的成功实施将有助于快速组装各种多环体系，包括一些在化学文献中不太常见的体系。还可以实现对特权配体框架的随时访问。成功的结果应该对任何需要合成新分子的化学活动领域产生影响，例如在制药、农业和化学工业中。此外，该项目承诺为各级学生提供优秀的培训工具，包括那些来自历史上代表性不足的群体的学生。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Liming Zhang of Department of Chemistry at the University of California, Santa Barbara, aims to study the reactivities of two novel and reactive gold intermediates, gold vinylidene and gold aryne complex, and develop versatile reactions based on them that would be operationally simple, high yielding, and robust and offer unique/unprecedented access to important new skeletons. These procedures will be used in the synthesis of highly complex natural and unnatural products such as polycyclic hydrocarbons and heterocycles. Successful implementation of these strategies will provide for the rapid assembly of a variety of polycyclic systems, including some less commonly found in the chemical literature. Ready access to privileged ligand frameworks may also be achieved. Successful outcomes should have an impact on any area of chemical activity where the syntheses of novel molecules are needed, such as in the pharmaceutical, agricultural and chemical industries. Moreover, the project promises to provide excellent training vehicles of students at all levels, including those from historically underrepresented groups.