Analysis of DNA Sequence Recognition by Enzymes
Analysis of DNA Sequence Recognition by Enzymes
批准号:
8818673
负责人:
Robert Blumenthal
金额:
$22.06万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-03-01 至 1992-08-31
中文摘要
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英文摘要
The overall goal is to understand the structural basis of sequence recognition by DNA binding proteins. These studies have centered on the type II restriction-modification systems of bacteria, and in particular on the Pvu II system that was previously cloned from Proteus vulgaris. Four proteins that recognize the same DNA sequence which includes the Pvu II proteins will be characterized and compared. This comparison will be both structural and functional, and is intended to indicate the extent to which functionally-related proteins recognizing a common base sequences show structural homologies. The recognition of specific DNA sequences by proteins is so crucial to so many cellular processes that no mature understanding of cell physiology will be possible without understanding the basis of this recognition. These processes include promoter selection by RNA polymerases, the action of repressors, activators, enhancer-modulation, genetic recombination and transposition, and targeted DNA repair. Dr. Blumenthal is well trained for the work described here.
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会议论文
Regulation of Type II Restriction-Modification Systems
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批准号:0964728
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项目类别:Continuing Grant
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资助金额:$57.0万
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财政年份:2010
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负责人:Robert Blumenthal
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依托单位:
Genetic Switch Controlled by an Unusual Family of Transcription Activators
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批准号:0516692
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项目类别:Continuing Grant
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资助金额:$43.0万
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财政年份:2005
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负责人:Robert Blumenthal
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依托单位:
FASEB Conference on Biological Methylation: July 17-22, 1999, Vermont Academy, Saxton's River, VT
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批准号:9816744
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项目类别:Standard Grant
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资助金额:$1.0万
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财政年份:1999
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负责人:Robert Blumenthal
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依托单位:
Mechanism of Action of an Unusual Mobile Regulatory Cassette: The C Genes of Restriction-Modification Systems
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批准号:9904523
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项目类别:Continuing Grant
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资助金额:$35.0万
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财政年份:1999
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负责人:Robert Blumenthal
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依托单位:
How are Restriction Systems Controlled, and How Do They Recognize DNA Sequences?
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批准号:9631137
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项目类别:Continuing Grant
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资助金额:$27.43万
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财政年份:1996
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负责人:Robert Blumenthal
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依托单位:
Analysis of DNA Sequence Recognition by Three Types of Sequence-Specific Protein
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批准号:9205248
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项目类别:Continuing Grant
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资助金额:$36.8万
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财政年份:1992
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负责人:Robert Blumenthal
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依托单位:
Mathematical Sciences: Research and Workshop in Markov Processes
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批准号:8601782
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项目类别:Standard Grant
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资助金额:$1.24万
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财政年份:1986
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负责人:Robert Blumenthal
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依托单位:
Regulation and Biochemistry of Restriction Endonucleases
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批准号:8409652
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项目类别:Continuing Grant
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资助金额:$13.9万
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财政年份:1984
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负责人:Robert Blumenthal
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依托单位:
Regulation and Biochemistry of Restriction Endonucleases
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批准号:8201953
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项目类别:Standard Grant
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资助金额:$7.5万
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财政年份:1982
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负责人:Robert Blumenthal
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依托单位:
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