Iron regulatory proteins: pathophysiological functions in metabolism and cancer
Iron regulatory proteins: pathophysiological functions in metabolism and cancer
批准号:
266346
负责人:
Pantopoulos Konstantinos
金额:
$53.98万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-09-01 至 2017-09-01
中文摘要
铁调节蛋白IRP1和IRP2是调控细胞质中几种铁代谢基因表达的主开关。它们的表达对生命至关重要,因为缺乏这两种铁调节蛋白的小鼠在胚胎早期死亡
英文摘要
Iron regulatory proteins, IRP1 and IRP2, are master switches that regulate the expression of several iron metabolism genes in the cytoplasm of cells. Their expression is critical for life as mice lacking both iron regulatory proteins die early during embr
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