The role of protein glycosylation in erythropoiesis

蛋白质糖基化在红细胞生成中的作用

• 批准号: DP240100832
• 负责人: Prof Daniel Kolarich
• 金额: $ 56.09万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100832
• 关键词: role; protein; glycosylation; erythropoiesis

This project aims to understand how the sugar code of key-signalling proteins influences the development of red blood cells. This project expects to generate new fundamental knowledge in the area of stem cell signalling by innovative integration of biological and computational molecular characterisation techniques. The expected outcomes of this project include the development of novel workflows to study key regulators of cell development and the generation of new knowledge in stem cell signalling that will find applications in transforming stem cell therapies and associated research for future applications such as the laboratory manufacturing of red blood cells to close the availability gap for transfusion purposes.

该项目旨在了解关键信号蛋白的糖编码如何影响红细胞的发育。该项目希望通过生物和计算分子表征技术的创新整合，在干细胞信号传导领域产生新的基础知识。该项目的预期成果包括开发新的工作流程来研究细胞发育的关键调节因子，以及产生干细胞信号传导的新知识，这些知识将用于转化干细胞疗法和未来应用的相关研究，例如红细胞的实验室制造，以缩小输血目的的可用性差距。