Thermal Dependence of Electrical Activity in the Hamster Hippocampal Slice
仓鼠海马切片电活动的热依赖性
基本信息
- 批准号:8819973
- 负责人:
- 金额:$ 11.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-02-15 至 1991-10-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Dr. John Horowitz is continuing a line of experimentation which is designed to understand the neural activity underlying hibernation. He is studying the hippocampus because it is a region of the brain that appears to be involved in the entrance into and arousal from hibernation. By using the hippocampal slice preparation, the temperature of the bathing solution over the hippocampal neural network can be easily precisely set to match any temperature in the range observed in the CNS of animals entering hibernation. One set of experiments centers on the effect of temperature on long-term potentiation (LTP). LTP has captured the imagination of neuroscientists as a model with which to probe the mechanisms of learning and memory in the mammalian brain, but whether these mechanisms persist at low brain temperatures is unknown. Serotonin, a neurotransmitter, has been shown to play a role in an animal's entrance into hibernation. Therefore, the second set of experiments if to determine the effect of temperature on the serotonergic response of hippocampal neurons. This work is important because it will give us more insight into how the brain regulates and operates during low temperature states.
约翰·霍洛维茨博士正在继续进行一系列实验,旨在了解冬眠背后的神经活动。他正在研究海马体,因为这是大脑中的一个区域,似乎与进入冬眠和从冬眠中唤醒有关。通过使用海马片制备,海马神经网络上沐浴溶液的温度可以很容易地精确设置,以匹配进入冬眠的动物中枢神经系统观察到的任何温度范围。其中一组实验的中心是温度对长时程增强(LTP)的影响。LTP作为探索哺乳动物大脑中学习和记忆机制的模型,吸引了神经科学家的想象力,但这些机制是否在大脑温度较低的情况下持续存在尚不清楚。5-羟色胺是一种神经递质,已被证明在动物进入冬眠的过程中发挥了作用。因此,第二组实验旨在确定温度对海马神经元5-羟色胺能反应的影响。这项工作很重要,因为它将让我们更深入地了解大脑在低温状态下是如何调节和运作的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Horowitz其他文献
Takotsubo Syndrome Identified in the Intensive Care Unit: A Prospective Observational Study
- DOI:
10.1016/j.aucc.2018.11.060 - 发表时间:
2019-01-01 - 期刊:
- 影响因子:
- 作者:
Vicky Visvanathan;Angela Kucia;Benjamin Reddi;John Horowitz - 通讯作者:
John Horowitz
Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy
- DOI:
10.1186/1532-429x-17-s1-p259 - 发表时间:
2015-02-03 - 期刊:
- 影响因子:
- 作者:
Trevor Ahearn;Baljit Jagpal;Donnie Cameron;Bernice K Ng;Caroline Scally;David M Higgins;John Horowitz;Michael P Frenneaux;Dana K Dawson - 通讯作者:
Dana K Dawson
Antihypertrophic actions of NO-independent soluble guanylyl cyclase (sGC) ligands BAY 41-2272 and BAY 58-2667 in vitro
- DOI:
10.1186/1471-2210-9-s1-p59 - 发表时间:
2009-08-11 - 期刊:
- 影响因子:2.700
- 作者:
Rebecca Ritchie;Jennifer Irvine;Jane Love;John Horowitz;Johannes-Peter Stasch;Barbara Kemp-Harper - 通讯作者:
Barbara Kemp-Harper
Nitric oxide resistance at the platelet level: pathophysiology and therapeutic implications
- DOI:
10.1186/1471-2210-9-s1-s16 - 发表时间:
2009-08-11 - 期刊:
- 影响因子:2.700
- 作者:
John Horowitz;Yuliy Chirkov;Rebecca Ritchie - 通讯作者:
Rebecca Ritchie
ASYMMETRIC AND SYMMETRIC DIMETHYLARGININE ARE INEDEPENDENTLY ASSOCIATED WITH STROKE, BLEEDING AND DEATH IN ANTICOAGULATED PATIENTS WITH ATRIAL FIBRILLATION
- DOI:
10.1016/s0735-1097(20)30975-x - 发表时间:
2020-03-24 - 期刊:
- 影响因子:
- 作者:
Tymon Pol;Ziad Hijazi;Johan Westerbergh;Johan Lindbäck;John H. Alexander;Rafaele De Caterina;Christopher B. Granger;Tamila Heresztyn;Philippe Gabriel Steg;Renato Lopes;Agneta Siegbahn;John Horowitz;Lars Wallentin - 通讯作者:
Lars Wallentin
John Horowitz的其他文献
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{{ truncateString('John Horowitz', 18)}}的其他基金
Consensus and Disagreement on Probabilities: Implications for International Agreement on Policies to Mitigate Global Warming
关于概率的共识和分歧:对缓解全球变暖政策的国际协议的影响
- 批准号:
9109574 - 财政年份:1991
- 资助金额:
$ 11.38万 - 项目类别:
Standard Grant
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