Theoretical Study of Boron Anionic Heterocycles Derived fromHydroxamic Acids

该奖项支持合作研究， 纽约市亨特学院的约瑟夫·丹嫩伯格 纽约大学（CUNY）和 乌拉圭蒙得维的亚共和国大学。 他们将研究硼阴离子的理论 衍生自异羟肟酸的杂环。 分子 轨道计算将用于模拟 互变异构（结构异构体的相互转化） 取代的异羟肟酸 这些酸 尿素酶抑制剂，但不存在硼酸 所以这种酸和异羟肟酸之间的反应 酸将被研究。 这是化学家们最感兴趣的项目 两位合作者都是合格的， 多产 两者都有有效的 国际合作。 丹能伯格氏 实验技能补充理论技能， 乌拉圭人。 因此，该项目代表了一个 美国和美国之间的前沿化学合作 拉丁美洲科学家和一个很好的例子 实现科学发展观的目标 国家方案。

This award supports cooperative research between Joseph Dannenberg of Hunter College at the City University of New York (CUNY) and Oscar Ventura of the University of the Republic in Montevideo, Uruguay. They will study the theory of boron anionic heterocycles derived from hydroxamic acids. Molecular orbital calculations will be used to model the tautomerism (interconversion of structural isomers) of substituted hydroxamic acids. These acids are inhibitors of urease but not in the presence of boric acid so the reaction between this acid and hydroxamic acid will be studied. This is a project of fundamental interest to chemists and the two collaborators are well qualified and productive. Both have a history of effective international collaboration. Dannenberg's experimental skills complement the theoretical ones of the Uruguayan. Therefore this project represents a cooperation in frontier chemistry between U.S. and Latin American scientists and a good example of fulfillment of the goals of the Science in Developing Countries program.