Trigeminal Primary Afferent Organization and Development

三叉神经初级传入组织和发展

• 批准号: 8846642
• 负责人: Robert Rhoades
• 金额: $ 5.1万
• 依托单位: University of Toledo Health Science Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8846642&HistoricalAwards=false
• 关键词: Trigeminal; Primary; Afferent; Organization; Development

The brain is made aware of the external environment by sensory nerve cells. These cells connect both to small sense organs in the skin, and, at their other end, to nerve cells in the brain. In order for the organism to properly understand signals from its environment, the sensory nerve cell must make the proper connection between the correct sense organ and the correct brain cell. This project will examine how these proper connections are made during embryonic development. The normal connections between sensory nerve cells and the skin will be modified in a way that would occur after nerve damage. It will then be determined how changes in the sensory nerve cell's connections to the skin in turn changes which cells they connect to in the brain. This project has the potential to improve our understanding of the mechanisms that promote proper connections among nerve cells during embryonic development and during regeneration of nerves after injury.

感觉神经细胞使大脑意识到外部环境。这些细胞既连接到皮肤上的小感觉器官，又连接到大脑中的神经细胞。为了让生物体正确地理解来自其环境的信号，感觉神经细胞必须在正确的感觉器官和正确的脑细胞之间进行适当的连接。这个项目将研究这些适当的连接是如何在胚胎发育期间建立的。感觉神经细胞和皮肤之间的正常连接将以一种在神经损伤后发生的方式进行修改。然后将确定感觉神经细胞与皮肤连接的变化如何反过来改变它们连接到大脑中的哪些细胞。这个项目有可能提高我们对在胚胎发育和损伤后神经再生过程中促进神经细胞之间适当连接的机制的理解。