Can we exploit mRNA modifications to control protein expression?

我们可以利用 mRNA 修饰来控制蛋白质表达吗？

• 批准号: DP230101979
• 负责人: Prof Stuart Ralph
• 金额: $ 28.38万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101979
• 关键词: exploit; mRNA; modifications; control; protein

Genes are encoded by DNA but are transcribed into a message called RNA before they can be translated into protein. RNA can be chemically modified at a gene-specific level, and this modification has been central to the success of RNA vaccines against COVID-19. Despite the importance of these modifications in cellular life and in biotechnology, the role of the most abundant RNA modifications is unclear. This project will investigate how we can exploit RNA modifications to modulate protein expression in a tractable single-celled organism with a small genome, Plasmodium. This information is important because understanding gene regulation is fundamental to all life, and the role of RNA modifications is emerging as integral to biotechnology.

基因由 DNA 编码，但在翻译成蛋白质之前会被转录成称为 RNA 的信息。 RNA 可以在基因特异性水平上进行化学修饰，这种修饰对于针对 COVID-19 的 RNA 疫苗的成功至关重要。尽管这些修饰在细胞生命和生物技术中很重要，但最丰富的 RNA 修饰的作用尚不清楚。该项目将研究如何利用 RNA 修饰来调节具有小基因组的易处理单细胞生物（疟原虫）中的蛋白质表达。这些信息很重要，因为了解基因调控是所有生命的基础，并且 RNA 修饰的作用正在成为生物技术不可或缺的一部分。