Alternative splicing in apicomplexan parasites

顶端复门寄生虫中的选择性剪接

• 批准号: DP160100389
• 负责人: Prof Stuart Ralph
• 金额: $ 23.57万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100389
• 关键词: Alternative; splicing; apicomplexan; parasites

The project intends to provide a detailed picture of how alternative splicing is regulated in four biologically diverse apicomplexan parasites, and to explain why parasites need this molecular trick to survive. Alternative splicing is an important means by which organisms increase the diversity of proteins encoded by their genome. Although this mechanism is well studied in humans, little is known about the extent of this phenomenon in other organisms, nor how the process is regulated. The project plans to test if alternative splicing is required to transition between different life stages, just as alternative splicing is required for tissue differentiation in animals, and describe how alternative splicing contributes to apicomplexan proteome diversity.

该项目旨在提供关于四种生物多样性的顶复门寄生虫如何调节选择性剪接的详细图片，并解释为什么寄生虫需要这种分子技巧才能生存。选择性剪接是生物体增加其基因组编码的蛋白质多样性的重要手段。尽管这种机制在人类身上得到了很好的研究，但人们对这种现象在其他生物体中的程度以及该过程是如何调节的知之甚少。该项目计划测试不同生命阶段之间的过渡是否需要选择性剪接，就像动物组织分化需要选择性剪接一样，并描述选择性剪接如何促进顶端复合体蛋白质组多样性。