Presidential Young Investigator Award

主要研究方向为应用免疫学、生物分离、人工器官、蛋白质科学与工程。在应用免疫学领域，他对应用于生物技术和医学重要问题的各种现象感兴趣。这些包括：(1)抗原-抗体复合物的结构和动力学及其与各种血源性分子和细胞的相互作用的研究；(2)光活化药物的新型靶向治疗的发展；(3)淋巴因子活化淋巴样细胞的动力学研究。在人工器官领域，PI目前的研究包括通过用半透膜包裹胰腺或肝细胞来开发人工肝脏和人工胰腺。在生物分离领域，有几个；目前正在研究的新方法包括：(1)利用电场和高压进行亲和色谱分离，(2)开发亲和反胶束，(3)开发电控聚电解质膜技术。在蛋白质科学和工程领域，PI的研究兴趣在于定义在不同环境下有助于蛋白质稳定性的现象。

The PI's research interests are in the fields of applied immunology, bioseparations, artificial organs, and protein science and engineering. In the area of applied immunology, he has an interest in a variety of phenomena with application to important issues in biotechnology and medicine. These include: (1) studies on the structure and dynamics of antigen-antibody complexes and their interaction with various blood-borne molecules and cells, (2) development of novel targeting therapies with light-activatable drugs, and (3) studies of the dynamics of activation of lymphoid cells by lymphokines. In the area of artificial organs, the PI's current research involves development of an artificial liver and an artificial pancreas by encapsulating pancreatic or liver cells with semipermeable membranes. In the field of bioseparations, several; new approaches are under investigation including: (1) affinity chromatographic separations using electric fields and high pressure, (2) development of affinity reversed micelles, and (3) development of electrically controlled polyelectrolyte membrane technology. In the fields of protein science and engineering, the PI's research interests lie in defining the phenomena that contribute to protein stability in different environments.