Presidential Young Investigator Award: Synthetic Models of Large Molecule-Small Molecule Interaction (Chemistry)

总统青年研究员奖：大分子-小分子相互作用的合成模型（化学）

• 批准号: 8858059
• 负责人: Robert Armstrong
• 金额: $ 26.2万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8858059&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Synthetic

Dr. Armstrong is being given the Presidential Young Investigator Award from the Organic and Macromolecular Chemistry Program to support his research into the molecular-level interactions of proteins, DNA, RNA and small molecules. This work will provide the information required to synthesize the new generation molecules to be used in agriculture and medicine. The synthesis of modified polysaccaride is being undertaken to provide a means of controlling the linear distance between peptides and other substances in water soluble systems. A small DNA fragment has been synthesized that contains an internal "handle" to provide a better understanding of the local and global chiral environment of DNA. These two projects, if successful, will guide further work of the important interactions that are important in biochemical systems. In addition, the synthesis of the structurally interesting natural products echinosporin, calyculin A and carzinophilin are being synthesized. These will improve the understanding of the important DNA-inactivation processes.

阿姆斯特朗博士获得了有机和大分子化学项目颁发的总统青年研究员奖，以支持他对蛋白质、DNA、RNA和小分子之间分子水平相互作用的研究。这项工作将提供合成用于农业和医药的新一代分子所需的信息。人们正在进行修饰多糖的合成，以提供一种在水溶性系统中控制多肽和其他物质之间的线性距离的方法。为了更好地了解DNA的局部和全局手性环境，已经合成了一个包含内部“手柄”的小DNA片段。这两个项目如果成功，将指导生化系统中重要的重要相互作用的进一步工作。此外，还在合成结构感兴趣的天然产物棘球菌素、花盏花素A和卡津亲和素。这些将提高对重要的DNA失活过程的理解。