Presidential Young Investigator Award: Synthetic Models of Large Molecule-Small Molecule Interaction (Chemistry)

总统青年研究员奖：大分子-小分子相互作用的合成模型（化学）

• 批准号: 8858059
• 负责人: Robert Armstrong
• 金额: $ 26.2万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8858059&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Synthetic

Dr. Armstrong is being given the Presidential Young Investigator Award from the Organic and Macromolecular Chemistry Program to support his research into the molecular-level interactions of proteins, DNA, RNA and small molecules. This work will provide the information required to synthesize the new generation molecules to be used in agriculture and medicine. The synthesis of modified polysaccaride is being undertaken to provide a means of controlling the linear distance between peptides and other substances in water soluble systems. A small DNA fragment has been synthesized that contains an internal "handle" to provide a better understanding of the local and global chiral environment of DNA. These two projects, if successful, will guide further work of the important interactions that are important in biochemical systems. In addition, the synthesis of the structurally interesting natural products echinosporin, calyculin A and carzinophilin are being synthesized. These will improve the understanding of the important DNA-inactivation processes.

阿姆斯特朗博士被授予总统青年 有机和高分子研究者奖 化学计划，以支持他的研究， 蛋白质、DNA、RNA和小分子之间的分子水平相互作用 分子。 这项工作将提供所需的信息， 合成新一代分子， 农业和医药。 正在进行改性多糖的合成， 提供一种控制线性距离的方法， 水溶性系统中的肽和其他物质。 一 合成了一个小的DNA片段， 内部“处理”，以更好地了解 DNA的局部和全局手性环境。 这两 项目如果成功，将指导联合国系统的进一步工作。 在生物化学中重要的相互作用 系统. 此外，合成的结构 有趣的天然产物棘孢菌素，calyculin A和 正在合成嗜癌素。 这将改善 了解重要的DNA失活过程。