Whole-body and muscle myofibrillar protein degradation in response to insulin: a new non-invasive technique for use in elderly and cachectic patients

胰岛素响应的全身和肌肉肌原纤维蛋白降解：一种用于老年和恶病质患者的新型非侵入性技术

• 批准号: 281273
• 负责人: Theal Rebecca M
• 金额: $ 1.27万
• 依托单位: McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-02-01 至 2014-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=281273&lang=en
• 关键词: 3-Methylhistidine; Insulin; Protein Breakdown; Skeletal Muscle Atrophy; Ubiquitin Proteasome System

The muscle loss observed during aging (sarcopenia) and in cancer-associated cachexia is detrimental as it reduces the patient's physical function, autonomy, responses to therapy, immune responses, quality and duration of life. It could be due to impaired

在衰老（肌肉减少症）和癌症相关恶病质中观察到的肌肉损失是有害的，因为它降低了患者的身体功能、自主性、对治疗的反应、免疫反应、生活质量和持续时间。 这可能是由于受损