Hormonal Regulation of Lipid Metabolism in Fish

本研究将探讨激素对脂质代谢，特别是肝脏脂质代谢的作用和相互作用。肝脏是动物代谢的重要器官，然而，关于其脂肪储存作用的信息却很少。鱼类（奇努克鲑鱼、虹鳟鱼）具有在肝脏中储存脂肪的独特能力，是这些研究的模型。初步研究将集中在各种胰腺激素（胰岛素、胰高血糖素和生长抑素）在整个动物中的作用。一种特定激素的代谢作用以及这种激素与其他激素的相互作用将被检查。脂质代谢与碳水化合物代谢改变之间的关系以及肝细胞内操作的生化过程将被检查，以确定胰腺激素影响脂质代谢的机制。

In this study the action and interaction of hormones on lipid (fat) metabolism, particularly lipid metabolism in liver will be investigated. The liver is an important organ in animal metabolism, however, little information exists concerning its role as a fat store. Fish (chinook salmon, rainbow trout), which have a unique ability to store lipid in their liver, are the model for these studies. Initial investigations will focus on the actions of various pancreatic hormones (insulin, glucagon and somatostatin) in the whole animal. The metabolic action of a particular hormone as well as the interaction of that hormone with other hormones will be examined. The relationship between aspects of lipid metabolism and alteration in carbohydrate metabolism as well as the biochemical processes operating within the liver cell will be examined to determine the mechanisms by which pancreatic hormones influence lipid metabolism.